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Application of nanosonosensitizer materials in cancer sono-dynamic therapy
Sonodynamic therapy (SDT) is a novel non-invasive treatment for cancer combining low-intensity ultrasound and sonosensitizers. SDT activates sonosensitizers through ultrasound, releasing energy and generating reactive oxygen species to kill tumor cells. Compared with traditional photodynamic therapy...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376763/ https://www.ncbi.nlm.nih.gov/pubmed/36105955 http://dx.doi.org/10.1039/d2ra03786f |
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author | Hu, Chaotao Hou, Biao Xie, Songlin |
author_facet | Hu, Chaotao Hou, Biao Xie, Songlin |
author_sort | Hu, Chaotao |
collection | PubMed |
description | Sonodynamic therapy (SDT) is a novel non-invasive treatment for cancer combining low-intensity ultrasound and sonosensitizers. SDT activates sonosensitizers through ultrasound, releasing energy and generating reactive oxygen species to kill tumor cells. Compared with traditional photodynamic therapy (PDT), SDT is a promising anti-cancer therapy with the advantages of better targeting, deeper tissue penetration, and higher focusing ability. With the development and broad application of nanomaterials, novel sonosensitizers with tumor-targeting specificity can deliver to deep tumors and enhance the tumor microenvironment. In this review, we first review the mechanisms of sonodynamic therapy. In addition, we also focus on the current types of sonosensitizers and the latest design strategies of nanomaterials in sonosensitizers. Finally, we summarize the combined strategy of sonodynamic therapy. |
format | Online Article Text |
id | pubmed-9376763 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-93767632022-09-13 Application of nanosonosensitizer materials in cancer sono-dynamic therapy Hu, Chaotao Hou, Biao Xie, Songlin RSC Adv Chemistry Sonodynamic therapy (SDT) is a novel non-invasive treatment for cancer combining low-intensity ultrasound and sonosensitizers. SDT activates sonosensitizers through ultrasound, releasing energy and generating reactive oxygen species to kill tumor cells. Compared with traditional photodynamic therapy (PDT), SDT is a promising anti-cancer therapy with the advantages of better targeting, deeper tissue penetration, and higher focusing ability. With the development and broad application of nanomaterials, novel sonosensitizers with tumor-targeting specificity can deliver to deep tumors and enhance the tumor microenvironment. In this review, we first review the mechanisms of sonodynamic therapy. In addition, we also focus on the current types of sonosensitizers and the latest design strategies of nanomaterials in sonosensitizers. Finally, we summarize the combined strategy of sonodynamic therapy. The Royal Society of Chemistry 2022-08-15 /pmc/articles/PMC9376763/ /pubmed/36105955 http://dx.doi.org/10.1039/d2ra03786f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Hu, Chaotao Hou, Biao Xie, Songlin Application of nanosonosensitizer materials in cancer sono-dynamic therapy |
title | Application of nanosonosensitizer materials in cancer sono-dynamic therapy |
title_full | Application of nanosonosensitizer materials in cancer sono-dynamic therapy |
title_fullStr | Application of nanosonosensitizer materials in cancer sono-dynamic therapy |
title_full_unstemmed | Application of nanosonosensitizer materials in cancer sono-dynamic therapy |
title_short | Application of nanosonosensitizer materials in cancer sono-dynamic therapy |
title_sort | application of nanosonosensitizer materials in cancer sono-dynamic therapy |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376763/ https://www.ncbi.nlm.nih.gov/pubmed/36105955 http://dx.doi.org/10.1039/d2ra03786f |
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