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Regional connectivity drove bidirectional transmission of SARS-CoV-2 in the Middle East during travel restrictions
Regional connectivity and land travel have been identified as important drivers of SARS-CoV-2 transmission. However, the generalizability of this finding is understudied outside of well-sampled, highly connected regions. In this study, we investigated the relative contributions of regional and inter...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376901/ https://www.ncbi.nlm.nih.gov/pubmed/35970983 http://dx.doi.org/10.1038/s41467-022-32536-1 |
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| author | Parker, Edyth Anderson, Catelyn Zeller, Mark Tibi, Ahmad Havens, Jennifer L. Laroche, Geneviève Benlarbi, Mehdi Ariana, Ardeshir Robles-Sikisaka, Refugio Latif, Alaa Abdel Watts, Alexander Awidi, Abdalla Jaradat, Saied A. Gangavarapu, Karthik Ramesh, Karthik Kurzban, Ezra Matteson, Nathaniel L. Han, Alvin X. Hughes, Laura D. McGraw, Michelle Spencer, Emily Nicholson, Laura Khan, Kamran Suchard, Marc A. Wertheim, Joel O. Wohl, Shirlee Côté, Marceline Abdelnour, Amid Andersen, Kristian G. Abu-Dayyeh, Issa |
| author_facet | Parker, Edyth Anderson, Catelyn Zeller, Mark Tibi, Ahmad Havens, Jennifer L. Laroche, Geneviève Benlarbi, Mehdi Ariana, Ardeshir Robles-Sikisaka, Refugio Latif, Alaa Abdel Watts, Alexander Awidi, Abdalla Jaradat, Saied A. Gangavarapu, Karthik Ramesh, Karthik Kurzban, Ezra Matteson, Nathaniel L. Han, Alvin X. Hughes, Laura D. McGraw, Michelle Spencer, Emily Nicholson, Laura Khan, Kamran Suchard, Marc A. Wertheim, Joel O. Wohl, Shirlee Côté, Marceline Abdelnour, Amid Andersen, Kristian G. Abu-Dayyeh, Issa |
| author_sort | Parker, Edyth |
| collection | PubMed |
| description | Regional connectivity and land travel have been identified as important drivers of SARS-CoV-2 transmission. However, the generalizability of this finding is understudied outside of well-sampled, highly connected regions. In this study, we investigated the relative contributions of regional and intercontinental connectivity to the source-sink dynamics of SARS-CoV-2 for Jordan and the Middle East. By integrating genomic, epidemiological and travel data we show that the source of introductions into Jordan was dynamic across 2020, shifting from intercontinental seeding in the early pandemic to more regional seeding for the travel restrictions period. We show that land travel, particularly freight transport, drove introduction risk during the travel restrictions period. High regional connectivity and land travel also drove Jordan’s export risk. Our findings emphasize regional connectedness and land travel as drivers of transmission in the Middle East. |
| format | Online Article Text |
| id | pubmed-9376901 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-93769012022-08-15 Regional connectivity drove bidirectional transmission of SARS-CoV-2 in the Middle East during travel restrictions Parker, Edyth Anderson, Catelyn Zeller, Mark Tibi, Ahmad Havens, Jennifer L. Laroche, Geneviève Benlarbi, Mehdi Ariana, Ardeshir Robles-Sikisaka, Refugio Latif, Alaa Abdel Watts, Alexander Awidi, Abdalla Jaradat, Saied A. Gangavarapu, Karthik Ramesh, Karthik Kurzban, Ezra Matteson, Nathaniel L. Han, Alvin X. Hughes, Laura D. McGraw, Michelle Spencer, Emily Nicholson, Laura Khan, Kamran Suchard, Marc A. Wertheim, Joel O. Wohl, Shirlee Côté, Marceline Abdelnour, Amid Andersen, Kristian G. Abu-Dayyeh, Issa Nat Commun Article Regional connectivity and land travel have been identified as important drivers of SARS-CoV-2 transmission. However, the generalizability of this finding is understudied outside of well-sampled, highly connected regions. In this study, we investigated the relative contributions of regional and intercontinental connectivity to the source-sink dynamics of SARS-CoV-2 for Jordan and the Middle East. By integrating genomic, epidemiological and travel data we show that the source of introductions into Jordan was dynamic across 2020, shifting from intercontinental seeding in the early pandemic to more regional seeding for the travel restrictions period. We show that land travel, particularly freight transport, drove introduction risk during the travel restrictions period. High regional connectivity and land travel also drove Jordan’s export risk. Our findings emphasize regional connectedness and land travel as drivers of transmission in the Middle East. Nature Publishing Group UK 2022-08-15 /pmc/articles/PMC9376901/ /pubmed/35970983 http://dx.doi.org/10.1038/s41467-022-32536-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Parker, Edyth Anderson, Catelyn Zeller, Mark Tibi, Ahmad Havens, Jennifer L. Laroche, Geneviève Benlarbi, Mehdi Ariana, Ardeshir Robles-Sikisaka, Refugio Latif, Alaa Abdel Watts, Alexander Awidi, Abdalla Jaradat, Saied A. Gangavarapu, Karthik Ramesh, Karthik Kurzban, Ezra Matteson, Nathaniel L. Han, Alvin X. Hughes, Laura D. McGraw, Michelle Spencer, Emily Nicholson, Laura Khan, Kamran Suchard, Marc A. Wertheim, Joel O. Wohl, Shirlee Côté, Marceline Abdelnour, Amid Andersen, Kristian G. Abu-Dayyeh, Issa Regional connectivity drove bidirectional transmission of SARS-CoV-2 in the Middle East during travel restrictions |
| title | Regional connectivity drove bidirectional transmission of SARS-CoV-2 in the Middle East during travel restrictions |
| title_full | Regional connectivity drove bidirectional transmission of SARS-CoV-2 in the Middle East during travel restrictions |
| title_fullStr | Regional connectivity drove bidirectional transmission of SARS-CoV-2 in the Middle East during travel restrictions |
| title_full_unstemmed | Regional connectivity drove bidirectional transmission of SARS-CoV-2 in the Middle East during travel restrictions |
| title_short | Regional connectivity drove bidirectional transmission of SARS-CoV-2 in the Middle East during travel restrictions |
| title_sort | regional connectivity drove bidirectional transmission of sars-cov-2 in the middle east during travel restrictions |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376901/ https://www.ncbi.nlm.nih.gov/pubmed/35970983 http://dx.doi.org/10.1038/s41467-022-32536-1 |
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