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Phenotype‐informed polygenic risk scores are associated with worse outcome in individuals at risk of Alzheimer's disease

INTRODUCTION: Patients with predementia Alzheimer's disease (AD) and at‐risk subjects are targets for promising disease‐modifying treatments, and improved polygenic risk scores (PRSs) could improve early‐stage case selection. METHODS: Phenotype‐informed PRSs were developed by selecting AD‐assoc...

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Detalles Bibliográficos
Autores principales:	Nordengen, Kaja, Pålhaugen, Lene, Bettella, Francesco, Bahrami, Shahram, Selnes, Per, Jarholm, Jonas, Athanasiu, Lavinia, Shadrin, Alexey, Andreassen, Ole A., Fladby, Tormod
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376972/ https://www.ncbi.nlm.nih.gov/pubmed/35991219 http://dx.doi.org/10.1002/dad2.12350

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