Identification of RAD51–BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry

[Image: see text] RAD51 is an ATP-dependent recombinase, recruited by BRCA2 to mediate DNA double-strand breaks repair through homologous recombination and represents an attractive cancer drug target. Herein, we applied for the first-time protein-templated dynamic combinatorial chemistry on RAD51 as...

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Detalles Bibliográficos
Autores principales: Bagnolini, Greta, Balboni, Beatrice, Schipani, Fabrizio, Gioia, Dario, Veronesi, Marina, De Franco, Francesca, Kaya, Cansu, Jumde, Ravindra P., Ortega, Jose Antonio, Girotto, Stefania, Hirsch, Anna K. H., Roberti, Marinella, Cavalli, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377020/
https://www.ncbi.nlm.nih.gov/pubmed/35978685
http://dx.doi.org/10.1021/acsmedchemlett.2c00063

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