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Microdistribution of internal radiation dose in biological tissues exposed to (56)Mn dioxide microparticles

Manganese-56 ((56)Mn) was one of the dominant neutron-activated radionuclides during the first hours following the atomic-bombing of Hiroshima and Nagasaki. The radiation spectrum of (56)Mn and the radiation emission from excited levels of (56)Fe following (56)Mn beta-decay include gamma-quanta, bet...

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Autores principales: Stepanenko, Valeriy, Kaprin, Andrey, Ivanov, Sergey, Shegay, Peter, Bogacheva, Viktoria, Sato, Hitoshi, Shichijo, Kazuko, Toyoda, Shin, Kawano, Noriyuki, Ohtaki, Megu, Fujimoto, Nariaki, Endo, Satoru, Chaizhunusova, Nailya, Shabdarbaeva, Dariya, Zhumadilov, Kassym, Hoshi, Masaharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377032/
https://www.ncbi.nlm.nih.gov/pubmed/35968986
http://dx.doi.org/10.1093/jrr/rrac023
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author Stepanenko, Valeriy
Kaprin, Andrey
Ivanov, Sergey
Shegay, Peter
Bogacheva, Viktoria
Sato, Hitoshi
Shichijo, Kazuko
Toyoda, Shin
Kawano, Noriyuki
Ohtaki, Megu
Fujimoto, Nariaki
Endo, Satoru
Chaizhunusova, Nailya
Shabdarbaeva, Dariya
Zhumadilov, Kassym
Hoshi, Masaharu
author_facet Stepanenko, Valeriy
Kaprin, Andrey
Ivanov, Sergey
Shegay, Peter
Bogacheva, Viktoria
Sato, Hitoshi
Shichijo, Kazuko
Toyoda, Shin
Kawano, Noriyuki
Ohtaki, Megu
Fujimoto, Nariaki
Endo, Satoru
Chaizhunusova, Nailya
Shabdarbaeva, Dariya
Zhumadilov, Kassym
Hoshi, Masaharu
author_sort Stepanenko, Valeriy
collection PubMed
description Manganese-56 ((56)Mn) was one of the dominant neutron-activated radionuclides during the first hours following the atomic-bombing of Hiroshima and Nagasaki. The radiation spectrum of (56)Mn and the radiation emission from excited levels of (56)Fe following (56)Mn beta-decay include gamma-quanta, beta-particles, Auger electrons and X-rays. The dispersion of neutron activated (56)Mn in the air can lead to entering of radioactive microparticles into the lungs. The investigation of spatial microdistribution of an internal dose in biological tissue exposed to (56)Mn is an important matter with regards to the possible elevated irradiation of the lung alveoli and alveolar ducts. The Monte Carlo code (MCNP-4C) was used for the calculation of absorbed doses in biological tissue around (56)Mn dioxide microparticles. The estimated absorbed dose has a very essential gradient in the epithelium cells of lung alveoli and alveolar duct: from 61 mGy/decay on the surface of simple squamous cells of epithelium to 0.15 mGy/decay at distance of 0.3 μm, which is maximal cell thickness. It has been concluded that epithelial cells of these pulmonary microstructures are selectively irradiated by low-energy electrons: short-range component of beta-particles spectrum and Auger electrons. The data obtained are important for the interpretation of biological experiments implementing dispersed neutron-activated (56)Mn dioxide powder.
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spelling pubmed-93770322022-08-16 Microdistribution of internal radiation dose in biological tissues exposed to (56)Mn dioxide microparticles Stepanenko, Valeriy Kaprin, Andrey Ivanov, Sergey Shegay, Peter Bogacheva, Viktoria Sato, Hitoshi Shichijo, Kazuko Toyoda, Shin Kawano, Noriyuki Ohtaki, Megu Fujimoto, Nariaki Endo, Satoru Chaizhunusova, Nailya Shabdarbaeva, Dariya Zhumadilov, Kassym Hoshi, Masaharu J Radiat Res Supplement Article Manganese-56 ((56)Mn) was one of the dominant neutron-activated radionuclides during the first hours following the atomic-bombing of Hiroshima and Nagasaki. The radiation spectrum of (56)Mn and the radiation emission from excited levels of (56)Fe following (56)Mn beta-decay include gamma-quanta, beta-particles, Auger electrons and X-rays. The dispersion of neutron activated (56)Mn in the air can lead to entering of radioactive microparticles into the lungs. The investigation of spatial microdistribution of an internal dose in biological tissue exposed to (56)Mn is an important matter with regards to the possible elevated irradiation of the lung alveoli and alveolar ducts. The Monte Carlo code (MCNP-4C) was used for the calculation of absorbed doses in biological tissue around (56)Mn dioxide microparticles. The estimated absorbed dose has a very essential gradient in the epithelium cells of lung alveoli and alveolar duct: from 61 mGy/decay on the surface of simple squamous cells of epithelium to 0.15 mGy/decay at distance of 0.3 μm, which is maximal cell thickness. It has been concluded that epithelial cells of these pulmonary microstructures are selectively irradiated by low-energy electrons: short-range component of beta-particles spectrum and Auger electrons. The data obtained are important for the interpretation of biological experiments implementing dispersed neutron-activated (56)Mn dioxide powder. Oxford University Press 2022-08-13 /pmc/articles/PMC9377032/ /pubmed/35968986 http://dx.doi.org/10.1093/jrr/rrac023 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Supplement Article
Stepanenko, Valeriy
Kaprin, Andrey
Ivanov, Sergey
Shegay, Peter
Bogacheva, Viktoria
Sato, Hitoshi
Shichijo, Kazuko
Toyoda, Shin
Kawano, Noriyuki
Ohtaki, Megu
Fujimoto, Nariaki
Endo, Satoru
Chaizhunusova, Nailya
Shabdarbaeva, Dariya
Zhumadilov, Kassym
Hoshi, Masaharu
Microdistribution of internal radiation dose in biological tissues exposed to (56)Mn dioxide microparticles
title Microdistribution of internal radiation dose in biological tissues exposed to (56)Mn dioxide microparticles
title_full Microdistribution of internal radiation dose in biological tissues exposed to (56)Mn dioxide microparticles
title_fullStr Microdistribution of internal radiation dose in biological tissues exposed to (56)Mn dioxide microparticles
title_full_unstemmed Microdistribution of internal radiation dose in biological tissues exposed to (56)Mn dioxide microparticles
title_short Microdistribution of internal radiation dose in biological tissues exposed to (56)Mn dioxide microparticles
title_sort microdistribution of internal radiation dose in biological tissues exposed to (56)mn dioxide microparticles
topic Supplement Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377032/
https://www.ncbi.nlm.nih.gov/pubmed/35968986
http://dx.doi.org/10.1093/jrr/rrac023
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