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Microdistribution of internal radiation dose in biological tissues exposed to (56)Mn dioxide microparticles
Manganese-56 ((56)Mn) was one of the dominant neutron-activated radionuclides during the first hours following the atomic-bombing of Hiroshima and Nagasaki. The radiation spectrum of (56)Mn and the radiation emission from excited levels of (56)Fe following (56)Mn beta-decay include gamma-quanta, bet...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377032/ https://www.ncbi.nlm.nih.gov/pubmed/35968986 http://dx.doi.org/10.1093/jrr/rrac023 |
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author | Stepanenko, Valeriy Kaprin, Andrey Ivanov, Sergey Shegay, Peter Bogacheva, Viktoria Sato, Hitoshi Shichijo, Kazuko Toyoda, Shin Kawano, Noriyuki Ohtaki, Megu Fujimoto, Nariaki Endo, Satoru Chaizhunusova, Nailya Shabdarbaeva, Dariya Zhumadilov, Kassym Hoshi, Masaharu |
author_facet | Stepanenko, Valeriy Kaprin, Andrey Ivanov, Sergey Shegay, Peter Bogacheva, Viktoria Sato, Hitoshi Shichijo, Kazuko Toyoda, Shin Kawano, Noriyuki Ohtaki, Megu Fujimoto, Nariaki Endo, Satoru Chaizhunusova, Nailya Shabdarbaeva, Dariya Zhumadilov, Kassym Hoshi, Masaharu |
author_sort | Stepanenko, Valeriy |
collection | PubMed |
description | Manganese-56 ((56)Mn) was one of the dominant neutron-activated radionuclides during the first hours following the atomic-bombing of Hiroshima and Nagasaki. The radiation spectrum of (56)Mn and the radiation emission from excited levels of (56)Fe following (56)Mn beta-decay include gamma-quanta, beta-particles, Auger electrons and X-rays. The dispersion of neutron activated (56)Mn in the air can lead to entering of radioactive microparticles into the lungs. The investigation of spatial microdistribution of an internal dose in biological tissue exposed to (56)Mn is an important matter with regards to the possible elevated irradiation of the lung alveoli and alveolar ducts. The Monte Carlo code (MCNP-4C) was used for the calculation of absorbed doses in biological tissue around (56)Mn dioxide microparticles. The estimated absorbed dose has a very essential gradient in the epithelium cells of lung alveoli and alveolar duct: from 61 mGy/decay on the surface of simple squamous cells of epithelium to 0.15 mGy/decay at distance of 0.3 μm, which is maximal cell thickness. It has been concluded that epithelial cells of these pulmonary microstructures are selectively irradiated by low-energy electrons: short-range component of beta-particles spectrum and Auger electrons. The data obtained are important for the interpretation of biological experiments implementing dispersed neutron-activated (56)Mn dioxide powder. |
format | Online Article Text |
id | pubmed-9377032 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-93770322022-08-16 Microdistribution of internal radiation dose in biological tissues exposed to (56)Mn dioxide microparticles Stepanenko, Valeriy Kaprin, Andrey Ivanov, Sergey Shegay, Peter Bogacheva, Viktoria Sato, Hitoshi Shichijo, Kazuko Toyoda, Shin Kawano, Noriyuki Ohtaki, Megu Fujimoto, Nariaki Endo, Satoru Chaizhunusova, Nailya Shabdarbaeva, Dariya Zhumadilov, Kassym Hoshi, Masaharu J Radiat Res Supplement Article Manganese-56 ((56)Mn) was one of the dominant neutron-activated radionuclides during the first hours following the atomic-bombing of Hiroshima and Nagasaki. The radiation spectrum of (56)Mn and the radiation emission from excited levels of (56)Fe following (56)Mn beta-decay include gamma-quanta, beta-particles, Auger electrons and X-rays. The dispersion of neutron activated (56)Mn in the air can lead to entering of radioactive microparticles into the lungs. The investigation of spatial microdistribution of an internal dose in biological tissue exposed to (56)Mn is an important matter with regards to the possible elevated irradiation of the lung alveoli and alveolar ducts. The Monte Carlo code (MCNP-4C) was used for the calculation of absorbed doses in biological tissue around (56)Mn dioxide microparticles. The estimated absorbed dose has a very essential gradient in the epithelium cells of lung alveoli and alveolar duct: from 61 mGy/decay on the surface of simple squamous cells of epithelium to 0.15 mGy/decay at distance of 0.3 μm, which is maximal cell thickness. It has been concluded that epithelial cells of these pulmonary microstructures are selectively irradiated by low-energy electrons: short-range component of beta-particles spectrum and Auger electrons. The data obtained are important for the interpretation of biological experiments implementing dispersed neutron-activated (56)Mn dioxide powder. Oxford University Press 2022-08-13 /pmc/articles/PMC9377032/ /pubmed/35968986 http://dx.doi.org/10.1093/jrr/rrac023 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Supplement Article Stepanenko, Valeriy Kaprin, Andrey Ivanov, Sergey Shegay, Peter Bogacheva, Viktoria Sato, Hitoshi Shichijo, Kazuko Toyoda, Shin Kawano, Noriyuki Ohtaki, Megu Fujimoto, Nariaki Endo, Satoru Chaizhunusova, Nailya Shabdarbaeva, Dariya Zhumadilov, Kassym Hoshi, Masaharu Microdistribution of internal radiation dose in biological tissues exposed to (56)Mn dioxide microparticles |
title | Microdistribution of internal radiation dose in biological tissues exposed to (56)Mn dioxide microparticles |
title_full | Microdistribution of internal radiation dose in biological tissues exposed to (56)Mn dioxide microparticles |
title_fullStr | Microdistribution of internal radiation dose in biological tissues exposed to (56)Mn dioxide microparticles |
title_full_unstemmed | Microdistribution of internal radiation dose in biological tissues exposed to (56)Mn dioxide microparticles |
title_short | Microdistribution of internal radiation dose in biological tissues exposed to (56)Mn dioxide microparticles |
title_sort | microdistribution of internal radiation dose in biological tissues exposed to (56)mn dioxide microparticles |
topic | Supplement Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377032/ https://www.ncbi.nlm.nih.gov/pubmed/35968986 http://dx.doi.org/10.1093/jrr/rrac023 |
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