The overview of neutron-induced (56)Mn radioactive microparticle effects in experimental animals and related studies

Investigation into the risks associated with radiation exposure has been carried out on those exposed to radiation in Hiroshima and Nagasaki, Semipalatinsk and other parts of the world. These risks are used as a guidance standard for the protection for radiation workers and the general public when exposed to radiation, and it sets upper regulatory limits for the amount of radiation exposure. However, the effects of internal exposure to radioactive microparticles have not been considered in these studies. These effects cannot be ignored since the exposure dose increases are inversely proportional to the square of the distance to the vicinity of the particles and can exceed tens of thousands of mGy. So far, only retrospective studies of people who have been exposed to radiation have been conducted, therefore we hypothesized that animal experiments would be necessary to investigate these effects. As a result, we found specific effects of radioactive microparticles. One particularly noteworthy finding was that internal exposure to radioactive microparticles resulted in pathological changes that were more than 20 times greater than those caused by the same level of external exposure. In contrast, there were other results that showed no such effects, and the reasons for this discrepancy need to be clarified. We also conducted RNA expression experiments and found that there was a difference between external exposure to (60)Co gamma rays and internal exposure to (56)Mn microparticles. In the future, we will need to study the mechanisms behind these findings. If the mechanism can be confirmed, it is expected to lead to the development of protective and therapeutic methods.