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Overview and analysis of internal radiation dose estimates in experimental animals in a framework of international studies of the sprayed neutron-induced (56)Mn radioactive microparticles effects

The aim of overview is to present the pooled data of published internal dose estimates and the results of corresponding analysis of internal irradiation features of experimental mice and rats after exposure to sprayed neutron activated radioactive (56)MnO(2). These dose estimates were conducted in a...

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Detalles Bibliográficos
Autores principales: Stepanenko, Valeriy, Kaprin, Andrey, Ivanov, Sergey, Shegay, Peter, Bogacheva, Viktoria, Hoshi, Masaharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377035/
https://www.ncbi.nlm.nih.gov/pubmed/35968992
http://dx.doi.org/10.1093/jrr/rrac043
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author Stepanenko, Valeriy
Kaprin, Andrey
Ivanov, Sergey
Shegay, Peter
Bogacheva, Viktoria
Hoshi, Masaharu
author_facet Stepanenko, Valeriy
Kaprin, Andrey
Ivanov, Sergey
Shegay, Peter
Bogacheva, Viktoria
Hoshi, Masaharu
author_sort Stepanenko, Valeriy
collection PubMed
description The aim of overview is to present the pooled data of published internal dose estimates and the results of corresponding analysis of internal irradiation features of experimental mice and rats after exposure to sprayed neutron activated radioactive (56)MnO(2). These dose estimates were conducted in a framework of multicenter international study to investigate biological effects as a result of exposure to sprayed radioactive (56)MnO(2) microparticles. Radionuclide (56)Mn (T(1/2) = 2.58 h) is one of the main gamma-beta emitters during the first hours after neutron activation of soil following nuclear explosion. It was concluded that there are three groups of organs of mice and rats, the radiation doses of which differ by approximately an order of magnitude: the group with the highest radiation doses (large and small intestine, stomach, skin and lungs), the group with lowered radiation doses (eyes, esophagus, trachea), the group with the lowest radiation doses (liver, heart, kidneys). The radiation doses to organs are proportional to the activity of the sprayed radioactive powder. The distribution of internal radiation doses among organs of experimental mice of different strains but of the same age was practically the same in case of exposure to the same activity of sprayed (56)MnO(2) powder. Doses of internal irradiation of experimental mice substantially exceed the doses of internal irradiation of experimental rats exposed to the same activities of the sprayed (56)MnO(2) powder. The data presented in the overview can be helpful for further investigation and for interpretation of the biological effects of this type of irradiation.
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spelling pubmed-93770352022-08-16 Overview and analysis of internal radiation dose estimates in experimental animals in a framework of international studies of the sprayed neutron-induced (56)Mn radioactive microparticles effects Stepanenko, Valeriy Kaprin, Andrey Ivanov, Sergey Shegay, Peter Bogacheva, Viktoria Hoshi, Masaharu J Radiat Res Review Article The aim of overview is to present the pooled data of published internal dose estimates and the results of corresponding analysis of internal irradiation features of experimental mice and rats after exposure to sprayed neutron activated radioactive (56)MnO(2). These dose estimates were conducted in a framework of multicenter international study to investigate biological effects as a result of exposure to sprayed radioactive (56)MnO(2) microparticles. Radionuclide (56)Mn (T(1/2) = 2.58 h) is one of the main gamma-beta emitters during the first hours after neutron activation of soil following nuclear explosion. It was concluded that there are three groups of organs of mice and rats, the radiation doses of which differ by approximately an order of magnitude: the group with the highest radiation doses (large and small intestine, stomach, skin and lungs), the group with lowered radiation doses (eyes, esophagus, trachea), the group with the lowest radiation doses (liver, heart, kidneys). The radiation doses to organs are proportional to the activity of the sprayed radioactive powder. The distribution of internal radiation doses among organs of experimental mice of different strains but of the same age was practically the same in case of exposure to the same activity of sprayed (56)MnO(2) powder. Doses of internal irradiation of experimental mice substantially exceed the doses of internal irradiation of experimental rats exposed to the same activities of the sprayed (56)MnO(2) powder. The data presented in the overview can be helpful for further investigation and for interpretation of the biological effects of this type of irradiation. Oxford University Press 2022-08-13 /pmc/articles/PMC9377035/ /pubmed/35968992 http://dx.doi.org/10.1093/jrr/rrac043 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Review Article
Stepanenko, Valeriy
Kaprin, Andrey
Ivanov, Sergey
Shegay, Peter
Bogacheva, Viktoria
Hoshi, Masaharu
Overview and analysis of internal radiation dose estimates in experimental animals in a framework of international studies of the sprayed neutron-induced (56)Mn radioactive microparticles effects
title Overview and analysis of internal radiation dose estimates in experimental animals in a framework of international studies of the sprayed neutron-induced (56)Mn radioactive microparticles effects
title_full Overview and analysis of internal radiation dose estimates in experimental animals in a framework of international studies of the sprayed neutron-induced (56)Mn radioactive microparticles effects
title_fullStr Overview and analysis of internal radiation dose estimates in experimental animals in a framework of international studies of the sprayed neutron-induced (56)Mn radioactive microparticles effects
title_full_unstemmed Overview and analysis of internal radiation dose estimates in experimental animals in a framework of international studies of the sprayed neutron-induced (56)Mn radioactive microparticles effects
title_short Overview and analysis of internal radiation dose estimates in experimental animals in a framework of international studies of the sprayed neutron-induced (56)Mn radioactive microparticles effects
title_sort overview and analysis of internal radiation dose estimates in experimental animals in a framework of international studies of the sprayed neutron-induced (56)mn radioactive microparticles effects
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377035/
https://www.ncbi.nlm.nih.gov/pubmed/35968992
http://dx.doi.org/10.1093/jrr/rrac043
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