Structure-guided approach on the role of substitution on amide-linked bipyrazoles and its effect on their anti-inflammatory activity

A structure-guided modelling approach using COX-2 as a template was used to investigate the effect of replacing the chloro atom located at the chlorophenyl ring of amide-linked bipyrazole moieties, aiming at attaining better anti-inflammatory effect with a good safety profile. Bromo, fluoro, nitro,...

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Detalles Bibliográficos
Autores principales: Domiati, Souraya A., Abd El Galil, Khaled H., Abourehab, Mohammed A. S., Ibrahim, Tamer M., Ragab, Hanan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377232/
https://www.ncbi.nlm.nih.gov/pubmed/35950562
http://dx.doi.org/10.1080/14756366.2022.2109025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377232/
https://www.ncbi.nlm.nih.gov/pubmed/35950562
http://dx.doi.org/10.1080/14756366.2022.2109025

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