Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate

Mycophenolate mofetil (MMF) is an important immunosuppressant prodrug prescribed to prevent organ transplant rejection and to treat autoimmune diseases. MMF usage, however, is limited by severe gastrointestinal toxicity that is observed in approximately 45% of MMF recipients. The active form of the...

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Detalles Bibliográficos
Autores principales: Simpson, Joshua B., Sekela, Josh J., Graboski, Amanda L., Borlandelli, Valentina B., Bivins, Marissa M., Barker, Natalie K., Sorgen, Alicia A., Mordant, Angie L., Johnson, Rebecca L., Bhatt, Aadra P., Fodor, Anthony A., Herring, Laura E., Overkleeft, Hermen, Lee, John R., Redinbo, Matthew. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377255/
https://www.ncbi.nlm.nih.gov/pubmed/35953888
http://dx.doi.org/10.1080/19490976.2022.2107289

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