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A retrospective study of risk factors for early-onset neonatal sepsis with intrapartum maternal fever

BACKGROUND: Intrapartum fever is a well-known risk factor for adverse perinatal outcomes. In this study, we evaluated the clinical features for intrapartum maternal fever and investigated the risk factors for neonatal early-onset sepsis (EOS) with intrapartum maternal fever. METHODS: This retrospect...

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Autores principales: An, Hongmin, Zheng, Wei, Zhu, Qinghua, Chai, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377330/
https://www.ncbi.nlm.nih.gov/pubmed/35979478
http://dx.doi.org/10.7717/peerj.13834
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author An, Hongmin
Zheng, Wei
Zhu, Qinghua
Chai, Yun
author_facet An, Hongmin
Zheng, Wei
Zhu, Qinghua
Chai, Yun
author_sort An, Hongmin
collection PubMed
description BACKGROUND: Intrapartum fever is a well-known risk factor for adverse perinatal outcomes. In this study, we evaluated the clinical features for intrapartum maternal fever and investigated the risk factors for neonatal early-onset sepsis (EOS) with intrapartum maternal fever. METHODS: This retrospective cohort study involved a total of 568 neonates born to mothers with intrapartum maternal fever (temperature peak ≥38 degree Celsius) in Hangzhou Women’s Hospital from January 1st to December 31st, 2019. Neonates were assigned to the EOS and non-sepsis groups based on the diagnostic criteria for early-onset neonatal sepsis,. Demographic data, clinical information and laboratory test results were evaluated to assess the risk factors for EOS. RESULTS: A total of 568 neonates were included in this study, 84 of whom were diagnosed with EOS. The EOS group was significantly different from the non-sepsis group in 11 items including the both white blood cell (WBC) count and C-reactive protein (CRP) level of the mother before delivery (p < 0.05). A logistic regression analysis revealed that a high maternal WBC count before delivery (OR = 3.261, p = 0.019) and a maternal histological chorioamnionitis (HCA) diagnosis (OR = 5.608, p = 0.002) were independent risk factors for EOS. The optimal cut-off value for WBC (before delivery) was 16.75 × 10*(9)/L for EOS, according to receiver operating characteristic analysis (area under curve was 0.821). CONCLUSIONS: Elevated prenatal maternal WBC counts and maternal HCA diagnosis are both independently associated with EOS. Prenatal maternal WBC counts can be used as a sensitive indicator to predict EOS early.
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spelling pubmed-93773302022-08-16 A retrospective study of risk factors for early-onset neonatal sepsis with intrapartum maternal fever An, Hongmin Zheng, Wei Zhu, Qinghua Chai, Yun PeerJ Epidemiology BACKGROUND: Intrapartum fever is a well-known risk factor for adverse perinatal outcomes. In this study, we evaluated the clinical features for intrapartum maternal fever and investigated the risk factors for neonatal early-onset sepsis (EOS) with intrapartum maternal fever. METHODS: This retrospective cohort study involved a total of 568 neonates born to mothers with intrapartum maternal fever (temperature peak ≥38 degree Celsius) in Hangzhou Women’s Hospital from January 1st to December 31st, 2019. Neonates were assigned to the EOS and non-sepsis groups based on the diagnostic criteria for early-onset neonatal sepsis,. Demographic data, clinical information and laboratory test results were evaluated to assess the risk factors for EOS. RESULTS: A total of 568 neonates were included in this study, 84 of whom were diagnosed with EOS. The EOS group was significantly different from the non-sepsis group in 11 items including the both white blood cell (WBC) count and C-reactive protein (CRP) level of the mother before delivery (p < 0.05). A logistic regression analysis revealed that a high maternal WBC count before delivery (OR = 3.261, p = 0.019) and a maternal histological chorioamnionitis (HCA) diagnosis (OR = 5.608, p = 0.002) were independent risk factors for EOS. The optimal cut-off value for WBC (before delivery) was 16.75 × 10*(9)/L for EOS, according to receiver operating characteristic analysis (area under curve was 0.821). CONCLUSIONS: Elevated prenatal maternal WBC counts and maternal HCA diagnosis are both independently associated with EOS. Prenatal maternal WBC counts can be used as a sensitive indicator to predict EOS early. PeerJ Inc. 2022-08-12 /pmc/articles/PMC9377330/ /pubmed/35979478 http://dx.doi.org/10.7717/peerj.13834 Text en ©2022 An et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Epidemiology
An, Hongmin
Zheng, Wei
Zhu, Qinghua
Chai, Yun
A retrospective study of risk factors for early-onset neonatal sepsis with intrapartum maternal fever
title A retrospective study of risk factors for early-onset neonatal sepsis with intrapartum maternal fever
title_full A retrospective study of risk factors for early-onset neonatal sepsis with intrapartum maternal fever
title_fullStr A retrospective study of risk factors for early-onset neonatal sepsis with intrapartum maternal fever
title_full_unstemmed A retrospective study of risk factors for early-onset neonatal sepsis with intrapartum maternal fever
title_short A retrospective study of risk factors for early-onset neonatal sepsis with intrapartum maternal fever
title_sort retrospective study of risk factors for early-onset neonatal sepsis with intrapartum maternal fever
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377330/
https://www.ncbi.nlm.nih.gov/pubmed/35979478
http://dx.doi.org/10.7717/peerj.13834
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