Case Report of bla(NDM-7)-Harboring IncX3 Plasmid in ST196 Klebsiella quasipneumoniae in China

Klebsiella quasipneumoniae isolate SBH035 was recovered from a patient in Jiangsu Province, China. The isolate showed resistance to ampicillin, cefazolin, cefotaxime, meropenem, ceftazidime–avibactam, and fosfomycin. The carbapenemase-encoding gene bla(NDM-7) was identified, and whole genome sequenc...

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Detalles Bibliográficos
Autores principales: Sun, Lin, Li, Guiling, Meng, Nan, Wang, Zhenyu, Wang, Hanyun, Wang, Jing, Jiao, Xinan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377402/
https://www.ncbi.nlm.nih.gov/pubmed/35978724
http://dx.doi.org/10.2147/IDR.S374119
Descripción
Sumario:Klebsiella quasipneumoniae isolate SBH035 was recovered from a patient in Jiangsu Province, China. The isolate showed resistance to ampicillin, cefazolin, cefotaxime, meropenem, ceftazidime–avibactam, and fosfomycin. The carbapenemase-encoding gene bla(NDM-7) was identified, and whole genome sequencing analysis indicated that bla(NDM-7) was located in an IncX3 plasmid with a conserved structure of IS26-ΔcutA-tat-trpF-ble(MBL)-bla(NDM-7)-ISAba125-IS3000-ΔTn2. To date, this is the first identification of a bla(NDM-7)-harboring IncX3 plasmid in ST196 K. quasipneumoniae from a patient in China. Greater attention to controlling the dissemination of IncX3 plasmids is needed owing to potential horizontal transfer via mobile genetic elements.

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