Case Report of bla(NDM-7)-Harboring IncX3 Plasmid in ST196 Klebsiella quasipneumoniae in China

Klebsiella quasipneumoniae isolate SBH035 was recovered from a patient in Jiangsu Province, China. The isolate showed resistance to ampicillin, cefazolin, cefotaxime, meropenem, ceftazidime–avibactam, and fosfomycin. The carbapenemase-encoding gene bla(NDM-7) was identified, and whole genome sequenc...

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Autores principales: Sun, Lin, Li, Guiling, Meng, Nan, Wang, Zhenyu, Wang, Hanyun, Wang, Jing, Jiao, Xinan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377402/
https://www.ncbi.nlm.nih.gov/pubmed/35978724
http://dx.doi.org/10.2147/IDR.S374119
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author Sun, Lin
Li, Guiling
Meng, Nan
Wang, Zhenyu
Wang, Hanyun
Wang, Jing
Jiao, Xinan
author_facet Sun, Lin
Li, Guiling
Meng, Nan
Wang, Zhenyu
Wang, Hanyun
Wang, Jing
Jiao, Xinan
author_sort Sun, Lin
collection PubMed
description Klebsiella quasipneumoniae isolate SBH035 was recovered from a patient in Jiangsu Province, China. The isolate showed resistance to ampicillin, cefazolin, cefotaxime, meropenem, ceftazidime–avibactam, and fosfomycin. The carbapenemase-encoding gene bla(NDM-7) was identified, and whole genome sequencing analysis indicated that bla(NDM-7) was located in an IncX3 plasmid with a conserved structure of IS26-ΔcutA-tat-trpF-ble(MBL)-bla(NDM-7)-ISAba125-IS3000-ΔTn2. To date, this is the first identification of a bla(NDM-7)-harboring IncX3 plasmid in ST196 K. quasipneumoniae from a patient in China. Greater attention to controlling the dissemination of IncX3 plasmids is needed owing to potential horizontal transfer via mobile genetic elements.
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spelling pubmed-93774022022-08-16 Case Report of bla(NDM-7)-Harboring IncX3 Plasmid in ST196 Klebsiella quasipneumoniae in China Sun, Lin Li, Guiling Meng, Nan Wang, Zhenyu Wang, Hanyun Wang, Jing Jiao, Xinan Infect Drug Resist Case Report Klebsiella quasipneumoniae isolate SBH035 was recovered from a patient in Jiangsu Province, China. The isolate showed resistance to ampicillin, cefazolin, cefotaxime, meropenem, ceftazidime–avibactam, and fosfomycin. The carbapenemase-encoding gene bla(NDM-7) was identified, and whole genome sequencing analysis indicated that bla(NDM-7) was located in an IncX3 plasmid with a conserved structure of IS26-ΔcutA-tat-trpF-ble(MBL)-bla(NDM-7)-ISAba125-IS3000-ΔTn2. To date, this is the first identification of a bla(NDM-7)-harboring IncX3 plasmid in ST196 K. quasipneumoniae from a patient in China. Greater attention to controlling the dissemination of IncX3 plasmids is needed owing to potential horizontal transfer via mobile genetic elements. Dove 2022-08-11 /pmc/articles/PMC9377402/ /pubmed/35978724 http://dx.doi.org/10.2147/IDR.S374119 Text en © 2022 Sun et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Report
Sun, Lin
Li, Guiling
Meng, Nan
Wang, Zhenyu
Wang, Hanyun
Wang, Jing
Jiao, Xinan
Case Report of bla(NDM-7)-Harboring IncX3 Plasmid in ST196 Klebsiella quasipneumoniae in China
title Case Report of bla(NDM-7)-Harboring IncX3 Plasmid in ST196 Klebsiella quasipneumoniae in China
title_full Case Report of bla(NDM-7)-Harboring IncX3 Plasmid in ST196 Klebsiella quasipneumoniae in China
title_fullStr Case Report of bla(NDM-7)-Harboring IncX3 Plasmid in ST196 Klebsiella quasipneumoniae in China
title_full_unstemmed Case Report of bla(NDM-7)-Harboring IncX3 Plasmid in ST196 Klebsiella quasipneumoniae in China
title_short Case Report of bla(NDM-7)-Harboring IncX3 Plasmid in ST196 Klebsiella quasipneumoniae in China
title_sort case report of bla(ndm-7)-harboring incx3 plasmid in st196 klebsiella quasipneumoniae in china
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377402/
https://www.ncbi.nlm.nih.gov/pubmed/35978724
http://dx.doi.org/10.2147/IDR.S374119
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