Disruption of the lipolysis pathway results in stem cell death through a sterile immunity-like pathway in adult Drosophila

We previously showed that the Arf1-mediated lipolysis pathway sustains stem cells and cancer stem cells (CSCs); its ablation resulted in necrosis of stem cells and CSCs, which further triggers a systemic antitumor immune response. Here we show that knocking down Arf1 in intestinal stem cells (ISCs)...

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Detalles Bibliográficos
Autores principales: Aggarwal, Poonam, Liu, Zilun, Qian Cheng, Guang, Ram Singh, Shree, Shi, Chunmei, Chen, Ying, Sun, Ling V., Hou, Steven X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377423/
https://www.ncbi.nlm.nih.gov/pubmed/35732115
http://dx.doi.org/10.1016/j.celrep.2022.110958

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