Cargando…
RAD51 is a druggable target that sustains replication fork progression upon DNA replication stress
Solving the problems that replication forks encounter when synthesizing DNA is essential to prevent genomic instability. Besides their role in DNA repair in the G2 phase, several homologous recombination proteins, specifically RAD51, have prominent roles in the S phase. Using different cellular mode...
Autores principales: | Feu, Sonia, Unzueta, Fernando, Ercilla, Amaia, Pérez-Venteo, Alejandro, Jaumot, Montserrat, Agell, Neus |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377619/ https://www.ncbi.nlm.nih.gov/pubmed/35969531 http://dx.doi.org/10.1371/journal.pone.0266645 |
Ejemplares similares
-
New origin firing is inhibited by APC/C(Cdh1) activation in S-phase after severe replication stress
por: Ercilla, Amaia, et al.
Publicado: (2016) -
Cooperation of RAD51 and RAD54 in regression of a model replication fork
por: Bugreev, Dmitry V., et al.
Publicado: (2011) -
Non-enzymatic roles of human RAD51 at stalled replication forks
por: Mason, Jennifer M., et al.
Publicado: (2019) -
SUMO Modification Regulates BLM and RAD51 Interaction at Damaged Replication Forks
por: Ouyang, Karen J., et al.
Publicado: (2009) -
Sequential role of RAD51 paralog complexes in replication fork remodeling and restart
por: Berti, Matteo, et al.
Publicado: (2020)