Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression

DBC1 has been characterized as a key regulator of physiological and pathophysiological activities, such as DNA damage, senescence, and tumorigenesis. However, the mechanism by which the functional stability of DBC1 is regulated has yet to be elucidated. Here, we report that the ubiquitination-mediat...

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Detalles Bibliográficos
Autores principales: Liu, Qiangqiang, Luo, Qian, Feng, Jianyu, Zhao, Yanping, Ma, Biao, Cheng, Hongcheng, Zhao, Tian, Lei, Hong, Mu, Chenglong, Chen, Linbo, Meng, Yuanyuan, Zhang, Jiaojiao, Long, Yijia, Su, Jingyi, Chen, Guo, Li, Yanjun, Hu, Gang, Liao, Xudong, Chen, Quan, Zhu, Yushan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377797/
https://www.ncbi.nlm.nih.gov/pubmed/35913115
http://dx.doi.org/10.7554/eLife.81247

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