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The Role of Left Ventricular Outflow Tract Peak Velocity Measurement in Patients With Sepsis and Septic Shock

Aim To determine whether left ventricular outflow tract peak velocity is useful for the prediction of mortality in the early phase of sepsis or septic shock. Materials and methods Patients who were hospitalized in the emergency intensive care unit (ED-ICU) with the diagnosis of sepsis or septic shoc...

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Autores principales: Serin, Mustafa Emin, Ozluer, Yunus Emre, Kıy, Mehmet, Avcil, Mucahit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377864/
https://www.ncbi.nlm.nih.gov/pubmed/35989743
http://dx.doi.org/10.7759/cureus.26840
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author Serin, Mustafa Emin
Ozluer, Yunus Emre
Kıy, Mehmet
Avcil, Mucahit
author_facet Serin, Mustafa Emin
Ozluer, Yunus Emre
Kıy, Mehmet
Avcil, Mucahit
author_sort Serin, Mustafa Emin
collection PubMed
description Aim To determine whether left ventricular outflow tract peak velocity is useful for the prediction of mortality in the early phase of sepsis or septic shock. Materials and methods Patients who were hospitalized in the emergency intensive care unit (ED-ICU) with the diagnosis of sepsis or septic shock were consecutively enrolled into two groups (sepsis and septic shock groups) between January 2020 to February 2021. Patients who are pregnant and ≤18 years old were excluded. Demographics, vital parameters, the presence of mechanical ventilation, and vasopressor/inotropic support with the doses of the drugs used were recorded. Ultrasonographic measurements included bedside caval indexes and left ventricular outflow tract (LVOT) peak velocity measurements. The primary outcome was in-hospital and 28th-day mortality. Results A total of 116 patients with a median age of 72.5 (27 to 96) years were enrolled. Sixty-eight (58.6%) patients were male. According to a receiver operating characteristic (ROC) curve analysis, 75 cm/s was determined as a cut-off value to determine the efficacy of LVOT peak velocity measurement for discriminating septic shock from sepsis and predicting 28-day and in-hospital mortality. The patients were then regrouped as 54 (46.5%) patients in low and 62 (53.5%) patients in high-velocity groups according to the cut-off value. Both in-hospital and 28th-day mortality rates were significantly different between these groups (p<0.001). Conclusion Left ventricular outflow tract peak velocity measurement may be a useful adjunct for the prediction of mortality in septic patients. Vasopressors and volume status of the patient do not affect LVOT peak velocity measurements.
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spelling pubmed-93778642022-08-18 The Role of Left Ventricular Outflow Tract Peak Velocity Measurement in Patients With Sepsis and Septic Shock Serin, Mustafa Emin Ozluer, Yunus Emre Kıy, Mehmet Avcil, Mucahit Cureus Cardiology Aim To determine whether left ventricular outflow tract peak velocity is useful for the prediction of mortality in the early phase of sepsis or septic shock. Materials and methods Patients who were hospitalized in the emergency intensive care unit (ED-ICU) with the diagnosis of sepsis or septic shock were consecutively enrolled into two groups (sepsis and septic shock groups) between January 2020 to February 2021. Patients who are pregnant and ≤18 years old were excluded. Demographics, vital parameters, the presence of mechanical ventilation, and vasopressor/inotropic support with the doses of the drugs used were recorded. Ultrasonographic measurements included bedside caval indexes and left ventricular outflow tract (LVOT) peak velocity measurements. The primary outcome was in-hospital and 28th-day mortality. Results A total of 116 patients with a median age of 72.5 (27 to 96) years were enrolled. Sixty-eight (58.6%) patients were male. According to a receiver operating characteristic (ROC) curve analysis, 75 cm/s was determined as a cut-off value to determine the efficacy of LVOT peak velocity measurement for discriminating septic shock from sepsis and predicting 28-day and in-hospital mortality. The patients were then regrouped as 54 (46.5%) patients in low and 62 (53.5%) patients in high-velocity groups according to the cut-off value. Both in-hospital and 28th-day mortality rates were significantly different between these groups (p<0.001). Conclusion Left ventricular outflow tract peak velocity measurement may be a useful adjunct for the prediction of mortality in septic patients. Vasopressors and volume status of the patient do not affect LVOT peak velocity measurements. Cureus 2022-07-14 /pmc/articles/PMC9377864/ /pubmed/35989743 http://dx.doi.org/10.7759/cureus.26840 Text en Copyright © 2022, Serin et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Serin, Mustafa Emin
Ozluer, Yunus Emre
Kıy, Mehmet
Avcil, Mucahit
The Role of Left Ventricular Outflow Tract Peak Velocity Measurement in Patients With Sepsis and Septic Shock
title The Role of Left Ventricular Outflow Tract Peak Velocity Measurement in Patients With Sepsis and Septic Shock
title_full The Role of Left Ventricular Outflow Tract Peak Velocity Measurement in Patients With Sepsis and Septic Shock
title_fullStr The Role of Left Ventricular Outflow Tract Peak Velocity Measurement in Patients With Sepsis and Septic Shock
title_full_unstemmed The Role of Left Ventricular Outflow Tract Peak Velocity Measurement in Patients With Sepsis and Septic Shock
title_short The Role of Left Ventricular Outflow Tract Peak Velocity Measurement in Patients With Sepsis and Septic Shock
title_sort role of left ventricular outflow tract peak velocity measurement in patients with sepsis and septic shock
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377864/
https://www.ncbi.nlm.nih.gov/pubmed/35989743
http://dx.doi.org/10.7759/cureus.26840
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