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Investigation of the Immunoprotective Effect of Zinc on Ovalbumin Induced BALB/C Male Mice Based on NF-KB Signaling Pathway

Allergic rhinitis is one of the common chronic inflammatory diseases of the nasal mucosa. In order to investigate the effect of zinc on ovalbumin induced allergic rhinitis in BALB/C male mice based on NF-KB signaling pathway, thirty BALB/C male mice are randomly divided into three groups: control gr...

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Detalles Bibliográficos
Autores principales: Shi, Qiangyou, Shen, Xueliang, Long, Chao, Guo, Fan, Mi, Zhipeng, Li, Yongchun, Ma, Ruixia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377949/
https://www.ncbi.nlm.nih.gov/pubmed/36043146
http://dx.doi.org/10.1155/2022/8990629
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author Shi, Qiangyou
Shen, Xueliang
Long, Chao
Guo, Fan
Mi, Zhipeng
Li, Yongchun
Ma, Ruixia
author_facet Shi, Qiangyou
Shen, Xueliang
Long, Chao
Guo, Fan
Mi, Zhipeng
Li, Yongchun
Ma, Ruixia
author_sort Shi, Qiangyou
collection PubMed
description Allergic rhinitis is one of the common chronic inflammatory diseases of the nasal mucosa. In order to investigate the effect of zinc on ovalbumin induced allergic rhinitis in BALB/C male mice based on NF-KB signaling pathway, thirty BALB/C male mice are randomly divided into three groups: control group, ovalbumin induced allergic rhinitis asthma group and zinc intervention group. The experimental results show that Zinc supplementation in allergic asthma mice with allergic rhinitis correct the immune response of TH2 cells by inhibiting THE NF-KB signaling pathway, reduce the infiltration of inflammatory cells into lung nasal tissue, and reduce airway co-hyperreactivity to improve the clinical symptoms of asthma and play an immune protective role.
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spelling pubmed-93779492022-08-29 Investigation of the Immunoprotective Effect of Zinc on Ovalbumin Induced BALB/C Male Mice Based on NF-KB Signaling Pathway Shi, Qiangyou Shen, Xueliang Long, Chao Guo, Fan Mi, Zhipeng Li, Yongchun Ma, Ruixia Contrast Media Mol Imaging Research Article Allergic rhinitis is one of the common chronic inflammatory diseases of the nasal mucosa. In order to investigate the effect of zinc on ovalbumin induced allergic rhinitis in BALB/C male mice based on NF-KB signaling pathway, thirty BALB/C male mice are randomly divided into three groups: control group, ovalbumin induced allergic rhinitis asthma group and zinc intervention group. The experimental results show that Zinc supplementation in allergic asthma mice with allergic rhinitis correct the immune response of TH2 cells by inhibiting THE NF-KB signaling pathway, reduce the infiltration of inflammatory cells into lung nasal tissue, and reduce airway co-hyperreactivity to improve the clinical symptoms of asthma and play an immune protective role. Hindawi 2022-08-08 /pmc/articles/PMC9377949/ /pubmed/36043146 http://dx.doi.org/10.1155/2022/8990629 Text en Copyright © 2022 Qiangyou Shi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Shi, Qiangyou
Shen, Xueliang
Long, Chao
Guo, Fan
Mi, Zhipeng
Li, Yongchun
Ma, Ruixia
Investigation of the Immunoprotective Effect of Zinc on Ovalbumin Induced BALB/C Male Mice Based on NF-KB Signaling Pathway
title Investigation of the Immunoprotective Effect of Zinc on Ovalbumin Induced BALB/C Male Mice Based on NF-KB Signaling Pathway
title_full Investigation of the Immunoprotective Effect of Zinc on Ovalbumin Induced BALB/C Male Mice Based on NF-KB Signaling Pathway
title_fullStr Investigation of the Immunoprotective Effect of Zinc on Ovalbumin Induced BALB/C Male Mice Based on NF-KB Signaling Pathway
title_full_unstemmed Investigation of the Immunoprotective Effect of Zinc on Ovalbumin Induced BALB/C Male Mice Based on NF-KB Signaling Pathway
title_short Investigation of the Immunoprotective Effect of Zinc on Ovalbumin Induced BALB/C Male Mice Based on NF-KB Signaling Pathway
title_sort investigation of the immunoprotective effect of zinc on ovalbumin induced balb/c male mice based on nf-kb signaling pathway
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9377949/
https://www.ncbi.nlm.nih.gov/pubmed/36043146
http://dx.doi.org/10.1155/2022/8990629
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