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Prevalence of Treponema Pallidum Antibody among Volunteer Blood Donors in China
BACKGROUND: Infection with syphilis is still a major public health problem. The precise data for syphilis seroprevalence in the populations will help to develop a strategy for prevention and treatment of it. However, the data for syphilis prevalence in continuous years among volunteer blood donors i...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378002/ https://www.ncbi.nlm.nih.gov/pubmed/35979517 http://dx.doi.org/10.1155/2022/1668703 |
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author | Zheng, Xiaofan Ding, Wei Ling, Xia Shi, Jie Dong, Jie Yu, Guangshu Chen, Yan Li, Rui Xu, Lihong Li, Xiaotao Zhu, Hong Zhu, Faming Hu, Wei |
author_facet | Zheng, Xiaofan Ding, Wei Ling, Xia Shi, Jie Dong, Jie Yu, Guangshu Chen, Yan Li, Rui Xu, Lihong Li, Xiaotao Zhu, Hong Zhu, Faming Hu, Wei |
author_sort | Zheng, Xiaofan |
collection | PubMed |
description | BACKGROUND: Infection with syphilis is still a major public health problem. The precise data for syphilis seroprevalence in the populations will help to develop a strategy for prevention and treatment of it. However, the data for syphilis prevalence in continuous years among volunteer blood donors in China is rare. METHODS: A retrospective study for Treponema pallidum (TP) antibody in blood donors was conducted from January 2010 to December 2019 at the Blood Center of Zhejiang Province, China. TP antibody was detected with two different reagents using enzyme-linked immunosorbent assay and the only sample which was reactive in the two reagents was defined as seropositive. RESULTS: A total of 992,646 volunteer blood donors were analyzed and the positive rate of TP antibody in the blood donors was 0.43%. From 2010 to 2019, the positive rates of TP antibody were 0.53%, 0.51%, 0.51%, 0.43%, 0.36%, 0.18%, 0.11%, 0.12%, 0.11%, and 0.10%, respectively. The positive rates of TP antibody were significantly different among blood donor age group (p < 0.001), with the highest positive rate in 45–54-years-old group (0.93%). The positive rates of TP antibody in male and female blood donors were 0.44% and 0.41%, respectively. The positive rate was 0.57% among the first-time blood donors, which was significantly higher than that of the repeat blood donors (0.17%). The positive rate of TP antibody in blood donors decreased gradually with the increase of educational level. CONCLUSION: The syphilis seroprevalence is low in the blood donors of the Hangzhou area, and the positive rate of blood donors is associated with age, educational level, and times of blood donation. Increasing the number of repeat blood donations is helpful to improve blood safety. |
format | Online Article Text |
id | pubmed-9378002 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-93780022022-08-16 Prevalence of Treponema Pallidum Antibody among Volunteer Blood Donors in China Zheng, Xiaofan Ding, Wei Ling, Xia Shi, Jie Dong, Jie Yu, Guangshu Chen, Yan Li, Rui Xu, Lihong Li, Xiaotao Zhu, Hong Zhu, Faming Hu, Wei Can J Infect Dis Med Microbiol Research Article BACKGROUND: Infection with syphilis is still a major public health problem. The precise data for syphilis seroprevalence in the populations will help to develop a strategy for prevention and treatment of it. However, the data for syphilis prevalence in continuous years among volunteer blood donors in China is rare. METHODS: A retrospective study for Treponema pallidum (TP) antibody in blood donors was conducted from January 2010 to December 2019 at the Blood Center of Zhejiang Province, China. TP antibody was detected with two different reagents using enzyme-linked immunosorbent assay and the only sample which was reactive in the two reagents was defined as seropositive. RESULTS: A total of 992,646 volunteer blood donors were analyzed and the positive rate of TP antibody in the blood donors was 0.43%. From 2010 to 2019, the positive rates of TP antibody were 0.53%, 0.51%, 0.51%, 0.43%, 0.36%, 0.18%, 0.11%, 0.12%, 0.11%, and 0.10%, respectively. The positive rates of TP antibody were significantly different among blood donor age group (p < 0.001), with the highest positive rate in 45–54-years-old group (0.93%). The positive rates of TP antibody in male and female blood donors were 0.44% and 0.41%, respectively. The positive rate was 0.57% among the first-time blood donors, which was significantly higher than that of the repeat blood donors (0.17%). The positive rate of TP antibody in blood donors decreased gradually with the increase of educational level. CONCLUSION: The syphilis seroprevalence is low in the blood donors of the Hangzhou area, and the positive rate of blood donors is associated with age, educational level, and times of blood donation. Increasing the number of repeat blood donations is helpful to improve blood safety. Hindawi 2022-08-08 /pmc/articles/PMC9378002/ /pubmed/35979517 http://dx.doi.org/10.1155/2022/1668703 Text en Copyright © 2022 Xiaofan Zheng et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zheng, Xiaofan Ding, Wei Ling, Xia Shi, Jie Dong, Jie Yu, Guangshu Chen, Yan Li, Rui Xu, Lihong Li, Xiaotao Zhu, Hong Zhu, Faming Hu, Wei Prevalence of Treponema Pallidum Antibody among Volunteer Blood Donors in China |
title | Prevalence of Treponema Pallidum Antibody among Volunteer Blood Donors in China |
title_full | Prevalence of Treponema Pallidum Antibody among Volunteer Blood Donors in China |
title_fullStr | Prevalence of Treponema Pallidum Antibody among Volunteer Blood Donors in China |
title_full_unstemmed | Prevalence of Treponema Pallidum Antibody among Volunteer Blood Donors in China |
title_short | Prevalence of Treponema Pallidum Antibody among Volunteer Blood Donors in China |
title_sort | prevalence of treponema pallidum antibody among volunteer blood donors in china |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378002/ https://www.ncbi.nlm.nih.gov/pubmed/35979517 http://dx.doi.org/10.1155/2022/1668703 |
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