Cargando…

Remdesivir-induced emergence of SARS-CoV2 variants in patients with prolonged infection

We here investigate the impact of antiviral treatments such as remdesivir on intra-host genomic diversity and emergence of SARS-CoV2 variants in patients with a prolonged course of infection. Sequencing and variant analysis performed in 112 longitudinal respiratory samples from 14 SARS-CoV2-infected...

Descripción completa

Detalles Bibliográficos
Autores principales:	Heyer, Andreas, Günther, Thomas, Robitaille, Alexis, Lütgehetmann, Marc, Addo, Marylyn M., Jarczak, Dominik, Kluge, Stefan, Aepfelbacher, Martin, Schulze zur Wiesch, Julian, Fischer, Nicole, Grundhoff, Adam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378267/ https://www.ncbi.nlm.nih.gov/pubmed/36075217 http://dx.doi.org/10.1016/j.xcrm.2022.100735

Ejemplares similares

SARS-CoV-2 Reinfection in a Healthcare Worker Despite the Presence of Detectable Neutralizing Antibodies
por: Brehm, Thomas Theo, et al.
Publicado: (2021)

Sotrovimab in Hospitalized Patients with SARS-CoV-2 Omicron Variant Infection: a Propensity Score-Matched Retrospective Cohort Study
por: Woo, Marcel S., et al.
Publicado: (2022)

Rapid Automated Screening for SARS-CoV-2 B.1.617 Lineage Variants (Delta/Kappa) through a Versatile Toolset of qPCR-Based SNP Detection
por: Nörz, Dominik, et al.
Publicado: (2021)

Clinical Evaluation of a Fully-Automated High-Throughput Multiplex Screening-Assay to Detect and Differentiate the SARS-CoV-2 B.1.1.529 (Omicron) and B.1.617.2 (Delta) Lineage Variants
por: Nörz, Dominik, et al.
Publicado: (2022)

Clinical efficacy and in vitro neutralization capacity of monoclonal antibodies for severe acute respiratory syndrome coronavirus 2 delta and omicron variants
por: Brehm, Thomas Theo, et al.
Publicado: (2022)

Low SARS-CoV-2 infection rates and high vaccine-induced immunity among German healthcare workers at the end of the third wave of the COVID-19 pandemic
por: Brehm, Thomas Theo, et al.
Publicado: (2021)

Clinical characteristics and comparison of longitudinal qPCR results from different specimen types in a cohort of ambulatory and hospitalized patients infected with monkeypox virus.
por: Nörz, Dominik, et al.
Publicado: (2022)

Evidence of surface contamination in hospital rooms occupied by patients infected with monkeypox, Germany, June 2022
por: Nörz, Dominik, et al.
Publicado: (2022)

Three Separate Spike Antigen Exposures by COVID-19 Vaccination or SARS-CoV-2 Infection Elicit Strong Humoral Immune Responses in Healthcare Workers
por: Brehm, Thomas Theo, et al.
Publicado: (2022)

Comparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza
por: Brehm, Thomas Theo, et al.
Publicado: (2021)

Clinical evaluation of five different automated SARS-CoV-2 serology assays in a cohort of hospitalized COVID-19 patients
por: Pflüger, Lisa Sophie, et al.
Publicado: (2020)

Complete Genome Sequence of a SARS-CoV-2 Strain Isolated in Northern Germany
por: Pfefferle, Susanne, et al.
Publicado: (2020)

Comparing susceptibility and contagiousness in concurrent outbreaks with a non-VOC and the VOC SARS-CoV-2 variant B.1.1.7 in daycare centers in Hamburg, Germany
por: Nakel, Jacqueline, et al.
Publicado: (2022)

B cell analysis in SARS-CoV-2 versus malaria: Increased frequencies of plasmablasts and atypical memory B cells in COVID-19
por: Wildner, Nils H, et al.
Publicado: (2020)

Rapid Metagenomic Diagnostics for Suspected Outbreak of Severe Pneumonia
por: Fischer, Nicole, et al.
Publicado: (2014)

Rapid Adaptation of Established High-Throughput Molecular Testing Infrastructure for Monkeypox Virus Detection
por: Nörz, Dominik, et al.
Publicado: (2022)

Clinical Outcomes of SARS-CoV-2 Breakthrough Infections in Liver Transplant Recipients during the Omicron Wave
por: Herting, Anna, et al.
Publicado: (2023)

The Clinical Perspective on Hepatitis E
por: Horvatits, Thomas, et al.
Publicado: (2019)

High and Sustained Ex Vivo Frequency but Altered Phenotype of SARS-CoV-2-Specific CD4(+) T-Cells in an Anti-CD20-Treated Patient with Prolonged COVID-19
por: Cords, Leon, et al.
Publicado: (2022)

SARS Coronavirus-2 variant tracing within the first Coronavirus Disease 19 clusters in northern Germany
por: Pfefferle, Susanne, et al.
Publicado: (2021)

Evaluation of a fully automated high-throughput SARS-CoV-2 multiplex qPCR assay with built-in screening functionality for del-HV69/70- and N501Y variants such as B.1.1.7
por: Nörz, Dominik, et al.
Publicado: (2021)

Significance of Anti-Nuclear Antibodies and Cryoglobulins in Patients with Acute and Chronic HEV Infection
por: Horvatits, Thomas, et al.
Publicado: (2020)

Management der saisonalen Influenza 2017/2018: Erfahrungen an einem deutschen Universitätsklinikum
por: Kraef, Christian, et al.
Publicado: (2019)

Patient Characteristics and Clinical Course of COVID-19 Patients Treated at a German Tertiary Center during the First and Second Waves in the Year 2020
por: Brehm, Thomas Theo, et al.
Publicado: (2021)

Handling and accuracy of four rapid antigen tests for the diagnosis of SARS-CoV-2 compared to RT-qPCR
por: Olearo, Flaminia, et al.
Publicado: (2021)

Clinical evaluation of a SARS-CoV-2 RT-PCR assay on a fully automated system for rapid on-demand testing in the hospital setting
por: Nörz, Dominik, et al.
Publicado: (2020)

Targeting Endothelial Dysfunction in Eight Extreme-Critically Ill Patients with COVID-19 Using the Anti-Adrenomedullin Antibody Adrecizumab (HAM8101)
por: Karakas, Mahir, et al.
Publicado: (2020)

Malaria in the Time of COVID-19: Do Not Miss the Real Cause of Illness
por: Jochum, Johannes, et al.
Publicado: (2021)

Viral Dynamics of SARS-CoV-2 in Critically Ill Allogeneic Hematopoietic Stem Cell Transplant Recipients and Immunocompetent Patients with COVID-19
por: Roedl, Kevin, et al.
Publicado: (2021)

DAMIAN: an open source bioinformatics tool for fast, systematic and cohort based analysis of microorganisms in diagnostic samples
por: Alawi, Malik, et al.
Publicado: (2019)

Mathematical Modeling of Remdesivir to Treat COVID-19: Can Dosing Be Optimized?
por: Conway, Jessica M., et al.
Publicado: (2021)

Modifying a Diagnostic SARS-CoV-2 Spike PCR to Turn a Del69/70 Dropout into a Discriminatory On-Target Assay
por: Nörz, Dominik, et al.
Publicado: (2021)

Seroprevalence of SARS-CoV-2 antibodies among hospital workers in a German tertiary care center: A sequential follow-up study
por: Brehm, Thomas Theo, et al.
Publicado: (2021)

Multi-dimensional and longitudinal systems profiling reveals predictive pattern of severe COVID-19
por: Woo, Marcel S., et al.
Publicado: (2021)

Natural killer cell‐mediated ADCC in SARS‐CoV‐2‐infected individuals and vaccine recipients
por: Hagemann, Kerri, et al.
Publicado: (2022)

SARS-CoV2-specific Humoral and T-cell Immune Response After Second Vaccination in Liver Cirrhosis and Transplant Patients
por: Ruether, Darius F., et al.
Publicado: (2022)

Pushing beyond specifications: Evaluation of linearity and clinical performance of the cobas 6800/8800 SARS-CoV-2 RT-PCR assay for reliable quantification in blood and other materials outside recommendations
por: Nörz, Dominik, et al.
Publicado: (2020)

Respiratory muscle dysfunction in long-COVID patients
por: Hennigs, Jan K., et al.
Publicado: (2022)

Frequency of IRF5+ dendritic cells is associated with the TLR7-induced inflammatory cytokine response in SARS-CoV-2 infection
por: Cords, Leon, et al.
Publicado: (2023)

Erratum zu: Milde COVID-19-Verläufe bei Mitarbeitenden einer Universitätsklinik: Die „erste Welle“ am Universitätsklinikum Hamburg-Eppendorf
por: von Felden, Johann, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_2k6je53iba751tdb4de2dm8bvb