Cargando…
Comparison of Ondansetron versus Domperidone for treating vomiting in acute gastroenteritis in children at a resource limited setting of South Punjab, Pakistan
OBJECTIVES: To compare the efficacy of Ondansetron versus Domperidone for treating vomiting in acute gastroenteritis (AGE) in children at a resource limited emergency setting of South Punjab, Pakistan. METHODS: This open label randomized controlled trial was conducted at The Pediatric Emergency Depa...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Professional Medical Publications
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378405/ https://www.ncbi.nlm.nih.gov/pubmed/35991241 http://dx.doi.org/10.12669/pjms.38.6.5532 |
_version_ | 1784768549379637248 |
---|---|
author | Ahmad, Tauseef Zarafshan, Uzma Sahar, Bushra |
author_facet | Ahmad, Tauseef Zarafshan, Uzma Sahar, Bushra |
author_sort | Ahmad, Tauseef |
collection | PubMed |
description | OBJECTIVES: To compare the efficacy of Ondansetron versus Domperidone for treating vomiting in acute gastroenteritis (AGE) in children at a resource limited emergency setting of South Punjab, Pakistan. METHODS: This open label randomized controlled trial was conducted at The Pediatric Emergency Department of Tehshil Headquarter Hospital, Liaqatpur, Pakistan, from July 2020 to June 2021. A total of 300 children of both genders aged below 12 years of age having 3 or more non-bilious, non-bloody vomiting episodes within 24 hours and with suggestive signs and symptoms of AGE were enrolled and randomized (150 in each group). Efficacy of both drugs was compared in terms of need of 2(nd) dose within 15 minutes, cessation of vomiting at 6-hour and 24-hour follow up. RESULTS: Out of a total of 300 children, 162 (54.0%) were male. Mean age was 4.7±2.3 years. Twenty seven (18.0%) children in Ondansetron group required 2(nd) dose within 15 minutes while 38 (25.3%) children in Domperidone group required the 2(nd) dose (p=0.1232). Cessation of vomiting at 6-hour interval was noted among 126 (84.0%) children in Ondansetron group in comparison to 118 (78.7%) in Domperidone group (p=0.2359). It was revealed that 127/142 (89.4%) children in Ondansetron group had cessation of vomiting at 24-hours follow up while this was noted to be among 108/134 (80.6%) children in Domperidone group (p=0.0390). CONCLUSION: In comparison to Domperidone, Ondansetron was found to have better efficacy aiming cessation of AGE associated vomiting among children with mild to moderate dehydration. |
format | Online Article Text |
id | pubmed-9378405 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Professional Medical Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-93784052022-08-19 Comparison of Ondansetron versus Domperidone for treating vomiting in acute gastroenteritis in children at a resource limited setting of South Punjab, Pakistan Ahmad, Tauseef Zarafshan, Uzma Sahar, Bushra Pak J Med Sci Original Article OBJECTIVES: To compare the efficacy of Ondansetron versus Domperidone for treating vomiting in acute gastroenteritis (AGE) in children at a resource limited emergency setting of South Punjab, Pakistan. METHODS: This open label randomized controlled trial was conducted at The Pediatric Emergency Department of Tehshil Headquarter Hospital, Liaqatpur, Pakistan, from July 2020 to June 2021. A total of 300 children of both genders aged below 12 years of age having 3 or more non-bilious, non-bloody vomiting episodes within 24 hours and with suggestive signs and symptoms of AGE were enrolled and randomized (150 in each group). Efficacy of both drugs was compared in terms of need of 2(nd) dose within 15 minutes, cessation of vomiting at 6-hour and 24-hour follow up. RESULTS: Out of a total of 300 children, 162 (54.0%) were male. Mean age was 4.7±2.3 years. Twenty seven (18.0%) children in Ondansetron group required 2(nd) dose within 15 minutes while 38 (25.3%) children in Domperidone group required the 2(nd) dose (p=0.1232). Cessation of vomiting at 6-hour interval was noted among 126 (84.0%) children in Ondansetron group in comparison to 118 (78.7%) in Domperidone group (p=0.2359). It was revealed that 127/142 (89.4%) children in Ondansetron group had cessation of vomiting at 24-hours follow up while this was noted to be among 108/134 (80.6%) children in Domperidone group (p=0.0390). CONCLUSION: In comparison to Domperidone, Ondansetron was found to have better efficacy aiming cessation of AGE associated vomiting among children with mild to moderate dehydration. Professional Medical Publications 2022 /pmc/articles/PMC9378405/ /pubmed/35991241 http://dx.doi.org/10.12669/pjms.38.6.5532 Text en Copyright: © Pakistan Journal of Medical Sciences https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0 (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Ahmad, Tauseef Zarafshan, Uzma Sahar, Bushra Comparison of Ondansetron versus Domperidone for treating vomiting in acute gastroenteritis in children at a resource limited setting of South Punjab, Pakistan |
title | Comparison of Ondansetron versus Domperidone for treating vomiting in acute gastroenteritis in children at a resource limited setting of South Punjab, Pakistan |
title_full | Comparison of Ondansetron versus Domperidone for treating vomiting in acute gastroenteritis in children at a resource limited setting of South Punjab, Pakistan |
title_fullStr | Comparison of Ondansetron versus Domperidone for treating vomiting in acute gastroenteritis in children at a resource limited setting of South Punjab, Pakistan |
title_full_unstemmed | Comparison of Ondansetron versus Domperidone for treating vomiting in acute gastroenteritis in children at a resource limited setting of South Punjab, Pakistan |
title_short | Comparison of Ondansetron versus Domperidone for treating vomiting in acute gastroenteritis in children at a resource limited setting of South Punjab, Pakistan |
title_sort | comparison of ondansetron versus domperidone for treating vomiting in acute gastroenteritis in children at a resource limited setting of south punjab, pakistan |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378405/ https://www.ncbi.nlm.nih.gov/pubmed/35991241 http://dx.doi.org/10.12669/pjms.38.6.5532 |
work_keys_str_mv | AT ahmadtauseef comparisonofondansetronversusdomperidonefortreatingvomitinginacutegastroenteritisinchildrenataresourcelimitedsettingofsouthpunjabpakistan AT zarafshanuzma comparisonofondansetronversusdomperidonefortreatingvomitinginacutegastroenteritisinchildrenataresourcelimitedsettingofsouthpunjabpakistan AT saharbushra comparisonofondansetronversusdomperidonefortreatingvomitinginacutegastroenteritisinchildrenataresourcelimitedsettingofsouthpunjabpakistan |