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Effect of pre-operative administration of single-dose of gabapentin on postop surgical pain in patients undergoing sternotomy for CABG

OBJECTIVE: To investigate the efficacy of perioperative administration of a single dose of gabapentin on postoperative pain in patients undergoing sternotomy for CABG. METHODS: A cross-sectional analytical study was conducted at the cardiology ward of Ch. Pervaiz Elahi Institute of Cardiology, Multa...

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Autores principales: Ilyas, Kashaf, Latif, Rukhsana, Hafeez, Zainab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378414/
https://www.ncbi.nlm.nih.gov/pubmed/35991246
http://dx.doi.org/10.12669/pjms.38.6.5518
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author Ilyas, Kashaf
Latif, Rukhsana
Hafeez, Zainab
author_facet Ilyas, Kashaf
Latif, Rukhsana
Hafeez, Zainab
author_sort Ilyas, Kashaf
collection PubMed
description OBJECTIVE: To investigate the efficacy of perioperative administration of a single dose of gabapentin on postoperative pain in patients undergoing sternotomy for CABG. METHODS: A cross-sectional analytical study was conducted at the cardiology ward of Ch. Pervaiz Elahi Institute of Cardiology, Multan, form 9(th) June 2020to 9(th) June 2021. The participants were consecutively enrolled in the Gabapentin group, who received 1200 mg of Gabapentin two hours before the surgery for the two days, and the placebo group. The outcomes measurement involved the need for fentanyl intake in the first two postoperative days; pain at rest and in the moment in the first three postoperative days; postsurgical sleep scores; and patients reported quality of recovery. RESULTS: A total of 50 patients were enrolled in the study, 25 in each group. No significant difference was found between the two groups in terms of fentanyl intake, sleep scores, visual analog pain score, and the need for any adjunctive pain medication (p>0.05). Similarly, no significant difference was found in terms of occurrence of side-effects and quality of recovery (p>0.05). CONCLUSION: Pre-operative administration of a single dose of Gabapentin doesn’t significantly influence the post-operative pain, opioid consumption, sleep quality, or quality of recovery in patients undergoing cardiac surgery.
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spelling pubmed-93784142022-08-19 Effect of pre-operative administration of single-dose of gabapentin on postop surgical pain in patients undergoing sternotomy for CABG Ilyas, Kashaf Latif, Rukhsana Hafeez, Zainab Pak J Med Sci Original Article OBJECTIVE: To investigate the efficacy of perioperative administration of a single dose of gabapentin on postoperative pain in patients undergoing sternotomy for CABG. METHODS: A cross-sectional analytical study was conducted at the cardiology ward of Ch. Pervaiz Elahi Institute of Cardiology, Multan, form 9(th) June 2020to 9(th) June 2021. The participants were consecutively enrolled in the Gabapentin group, who received 1200 mg of Gabapentin two hours before the surgery for the two days, and the placebo group. The outcomes measurement involved the need for fentanyl intake in the first two postoperative days; pain at rest and in the moment in the first three postoperative days; postsurgical sleep scores; and patients reported quality of recovery. RESULTS: A total of 50 patients were enrolled in the study, 25 in each group. No significant difference was found between the two groups in terms of fentanyl intake, sleep scores, visual analog pain score, and the need for any adjunctive pain medication (p>0.05). Similarly, no significant difference was found in terms of occurrence of side-effects and quality of recovery (p>0.05). CONCLUSION: Pre-operative administration of a single dose of Gabapentin doesn’t significantly influence the post-operative pain, opioid consumption, sleep quality, or quality of recovery in patients undergoing cardiac surgery. Professional Medical Publications 2022 /pmc/articles/PMC9378414/ /pubmed/35991246 http://dx.doi.org/10.12669/pjms.38.6.5518 Text en Copyright: © Pakistan Journal of Medical Sciences https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0 (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ilyas, Kashaf
Latif, Rukhsana
Hafeez, Zainab
Effect of pre-operative administration of single-dose of gabapentin on postop surgical pain in patients undergoing sternotomy for CABG
title Effect of pre-operative administration of single-dose of gabapentin on postop surgical pain in patients undergoing sternotomy for CABG
title_full Effect of pre-operative administration of single-dose of gabapentin on postop surgical pain in patients undergoing sternotomy for CABG
title_fullStr Effect of pre-operative administration of single-dose of gabapentin on postop surgical pain in patients undergoing sternotomy for CABG
title_full_unstemmed Effect of pre-operative administration of single-dose of gabapentin on postop surgical pain in patients undergoing sternotomy for CABG
title_short Effect of pre-operative administration of single-dose of gabapentin on postop surgical pain in patients undergoing sternotomy for CABG
title_sort effect of pre-operative administration of single-dose of gabapentin on postop surgical pain in patients undergoing sternotomy for cabg
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378414/
https://www.ncbi.nlm.nih.gov/pubmed/35991246
http://dx.doi.org/10.12669/pjms.38.6.5518
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