Malic Enzyme 1 Absence in Synovial Sarcoma Shifts Antioxidant System Dependence and Increases Sensitivity to Ferroptosis Induction with ACXT-3102

PURPOSE: To investigate the metabolism of synovial sarcoma (SS) and elucidate the effect of malic enzyme 1 absence on SS redox homeostasis. EXPERIMENTAL DESIGN: ME1 expression was measured in SS clinical samples, SS cell lines, and tumors from an SS mouse model. The effect of ME1 absence on glucose...

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Detalles Bibliográficos
Autores principales: Brashears, Caitlyn B., Prudner, Bethany C., Rathore, Richa, Caldwell, Katharine E., Dehner, Carina A., Buchanan, Jane L., Lange, Sara E.S., Poulin, Neal, Sehn, Jennifer K., Roszik, Jason, Spitzer, Dirk, Jones, Kevin B., O'Keefe, Regis, Nielsen, Torsten O., Taylor, Eric B., Held, Jason M., Hawkins, William, Van Tine, Brian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378556/
https://www.ncbi.nlm.nih.gov/pubmed/35421237
http://dx.doi.org/10.1158/1078-0432.CCR-22-0470

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