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Exploratory analysis of eating- and physical activity-related outcomes from a randomized controlled trial for weight loss maintenance with exercise and liraglutide single or combination treatment

Weight regain after weight loss remains a major challenge in obesity treatment and may involve alteration of eating and sedentary behavior after weight loss. In this randomized, controlled, double-blind trial, adults with obesity were randomized, in a 1:1:1:1 ratio stratified by sex and age group (&...

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Autores principales: Jensen, Simon Birk Kjær, Janus, Charlotte, Lundgren, Julie Rehné, Juhl, Christian Rimer, Sandsdal, Rasmus Michael, Olsen, Lisa Møller, Andresen, Anne, Borg, Signe Amalie, Jacobsen, Ida Christine, Finlayson, Graham, Stallknecht, Bente Merete, Holst, Jens Juul, Madsbad, Sten, Torekov, Signe Sørensen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378667/
https://www.ncbi.nlm.nih.gov/pubmed/35970829
http://dx.doi.org/10.1038/s41467-022-32307-y
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author Jensen, Simon Birk Kjær
Janus, Charlotte
Lundgren, Julie Rehné
Juhl, Christian Rimer
Sandsdal, Rasmus Michael
Olsen, Lisa Møller
Andresen, Anne
Borg, Signe Amalie
Jacobsen, Ida Christine
Finlayson, Graham
Stallknecht, Bente Merete
Holst, Jens Juul
Madsbad, Sten
Torekov, Signe Sørensen
author_facet Jensen, Simon Birk Kjær
Janus, Charlotte
Lundgren, Julie Rehné
Juhl, Christian Rimer
Sandsdal, Rasmus Michael
Olsen, Lisa Møller
Andresen, Anne
Borg, Signe Amalie
Jacobsen, Ida Christine
Finlayson, Graham
Stallknecht, Bente Merete
Holst, Jens Juul
Madsbad, Sten
Torekov, Signe Sørensen
author_sort Jensen, Simon Birk Kjær
collection PubMed
description Weight regain after weight loss remains a major challenge in obesity treatment and may involve alteration of eating and sedentary behavior after weight loss. In this randomized, controlled, double-blind trial, adults with obesity were randomized, in a 1:1:1:1 ratio stratified by sex and age group (<40 years and ≥40 years), to one-year weight loss maintenance with exercise, the GLP-1 receptor agonist liraglutide, or the combination, as compared with placebo, after low-calorie diet-induced weight loss. Primary outcome was change in body weight, which has been published. Here, we investigated the effects of weight loss maintenance with exercise, liraglutide, or the combination on weight loss-induced changes in the pre-specified explorative outcomes, eating and sedentary behavior in 130 participants who completed the trial according to the study protocol (exercise (n = 26), liraglutide (n = 36), combination (n = 29), and placebo (n = 39)). One year after weight loss, the placebo group had decreased postprandial appetite suppression score by 14%, and increased sedentary time by 31 min/day and regained weight. Liraglutide prevented the decrease in postprandial appetite suppression score compared with placebo (0% vs. −14%; P = 0.023) and maintained weight loss. Exercise after weight loss did not increase appetite or sedentary behavior compared with placebo, despite increased exercise energy expenditure and maintained weight loss. The combination of exercise and liraglutide increased cognitive restraint score (13% vs. −9%; P = 0.042), reflecting a conscious restriction of food intake, and decreased sedentary time by 41 min/day (−10 vs. 31 min/day; 95%CI, −82.3 to −0.2; P = 0.049) compared with placebo, which may have facilitated the additional weight loss. Targeting both eating and sedentary behavior could be the most effective for preventing weight regain. Trial registration: EudraCT number, 2015-005585-32; clinicaltrials.gov number, NCT04122716.
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spelling pubmed-93786672022-08-17 Exploratory analysis of eating- and physical activity-related outcomes from a randomized controlled trial for weight loss maintenance with exercise and liraglutide single or combination treatment Jensen, Simon Birk Kjær Janus, Charlotte Lundgren, Julie Rehné Juhl, Christian Rimer Sandsdal, Rasmus Michael Olsen, Lisa Møller Andresen, Anne Borg, Signe Amalie Jacobsen, Ida Christine Finlayson, Graham Stallknecht, Bente Merete Holst, Jens Juul Madsbad, Sten Torekov, Signe Sørensen Nat Commun Article Weight regain after weight loss remains a major challenge in obesity treatment and may involve alteration of eating and sedentary behavior after weight loss. In this randomized, controlled, double-blind trial, adults with obesity were randomized, in a 1:1:1:1 ratio stratified by sex and age group (<40 years and ≥40 years), to one-year weight loss maintenance with exercise, the GLP-1 receptor agonist liraglutide, or the combination, as compared with placebo, after low-calorie diet-induced weight loss. Primary outcome was change in body weight, which has been published. Here, we investigated the effects of weight loss maintenance with exercise, liraglutide, or the combination on weight loss-induced changes in the pre-specified explorative outcomes, eating and sedentary behavior in 130 participants who completed the trial according to the study protocol (exercise (n = 26), liraglutide (n = 36), combination (n = 29), and placebo (n = 39)). One year after weight loss, the placebo group had decreased postprandial appetite suppression score by 14%, and increased sedentary time by 31 min/day and regained weight. Liraglutide prevented the decrease in postprandial appetite suppression score compared with placebo (0% vs. −14%; P = 0.023) and maintained weight loss. Exercise after weight loss did not increase appetite or sedentary behavior compared with placebo, despite increased exercise energy expenditure and maintained weight loss. The combination of exercise and liraglutide increased cognitive restraint score (13% vs. −9%; P = 0.042), reflecting a conscious restriction of food intake, and decreased sedentary time by 41 min/day (−10 vs. 31 min/day; 95%CI, −82.3 to −0.2; P = 0.049) compared with placebo, which may have facilitated the additional weight loss. Targeting both eating and sedentary behavior could be the most effective for preventing weight regain. Trial registration: EudraCT number, 2015-005585-32; clinicaltrials.gov number, NCT04122716. Nature Publishing Group UK 2022-08-15 /pmc/articles/PMC9378667/ /pubmed/35970829 http://dx.doi.org/10.1038/s41467-022-32307-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Jensen, Simon Birk Kjær
Janus, Charlotte
Lundgren, Julie Rehné
Juhl, Christian Rimer
Sandsdal, Rasmus Michael
Olsen, Lisa Møller
Andresen, Anne
Borg, Signe Amalie
Jacobsen, Ida Christine
Finlayson, Graham
Stallknecht, Bente Merete
Holst, Jens Juul
Madsbad, Sten
Torekov, Signe Sørensen
Exploratory analysis of eating- and physical activity-related outcomes from a randomized controlled trial for weight loss maintenance with exercise and liraglutide single or combination treatment
title Exploratory analysis of eating- and physical activity-related outcomes from a randomized controlled trial for weight loss maintenance with exercise and liraglutide single or combination treatment
title_full Exploratory analysis of eating- and physical activity-related outcomes from a randomized controlled trial for weight loss maintenance with exercise and liraglutide single or combination treatment
title_fullStr Exploratory analysis of eating- and physical activity-related outcomes from a randomized controlled trial for weight loss maintenance with exercise and liraglutide single or combination treatment
title_full_unstemmed Exploratory analysis of eating- and physical activity-related outcomes from a randomized controlled trial for weight loss maintenance with exercise and liraglutide single or combination treatment
title_short Exploratory analysis of eating- and physical activity-related outcomes from a randomized controlled trial for weight loss maintenance with exercise and liraglutide single or combination treatment
title_sort exploratory analysis of eating- and physical activity-related outcomes from a randomized controlled trial for weight loss maintenance with exercise and liraglutide single or combination treatment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378667/
https://www.ncbi.nlm.nih.gov/pubmed/35970829
http://dx.doi.org/10.1038/s41467-022-32307-y
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