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Exploratory analysis of eating- and physical activity-related outcomes from a randomized controlled trial for weight loss maintenance with exercise and liraglutide single or combination treatment
Weight regain after weight loss remains a major challenge in obesity treatment and may involve alteration of eating and sedentary behavior after weight loss. In this randomized, controlled, double-blind trial, adults with obesity were randomized, in a 1:1:1:1 ratio stratified by sex and age group (&...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378667/ https://www.ncbi.nlm.nih.gov/pubmed/35970829 http://dx.doi.org/10.1038/s41467-022-32307-y |
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author | Jensen, Simon Birk Kjær Janus, Charlotte Lundgren, Julie Rehné Juhl, Christian Rimer Sandsdal, Rasmus Michael Olsen, Lisa Møller Andresen, Anne Borg, Signe Amalie Jacobsen, Ida Christine Finlayson, Graham Stallknecht, Bente Merete Holst, Jens Juul Madsbad, Sten Torekov, Signe Sørensen |
author_facet | Jensen, Simon Birk Kjær Janus, Charlotte Lundgren, Julie Rehné Juhl, Christian Rimer Sandsdal, Rasmus Michael Olsen, Lisa Møller Andresen, Anne Borg, Signe Amalie Jacobsen, Ida Christine Finlayson, Graham Stallknecht, Bente Merete Holst, Jens Juul Madsbad, Sten Torekov, Signe Sørensen |
author_sort | Jensen, Simon Birk Kjær |
collection | PubMed |
description | Weight regain after weight loss remains a major challenge in obesity treatment and may involve alteration of eating and sedentary behavior after weight loss. In this randomized, controlled, double-blind trial, adults with obesity were randomized, in a 1:1:1:1 ratio stratified by sex and age group (<40 years and ≥40 years), to one-year weight loss maintenance with exercise, the GLP-1 receptor agonist liraglutide, or the combination, as compared with placebo, after low-calorie diet-induced weight loss. Primary outcome was change in body weight, which has been published. Here, we investigated the effects of weight loss maintenance with exercise, liraglutide, or the combination on weight loss-induced changes in the pre-specified explorative outcomes, eating and sedentary behavior in 130 participants who completed the trial according to the study protocol (exercise (n = 26), liraglutide (n = 36), combination (n = 29), and placebo (n = 39)). One year after weight loss, the placebo group had decreased postprandial appetite suppression score by 14%, and increased sedentary time by 31 min/day and regained weight. Liraglutide prevented the decrease in postprandial appetite suppression score compared with placebo (0% vs. −14%; P = 0.023) and maintained weight loss. Exercise after weight loss did not increase appetite or sedentary behavior compared with placebo, despite increased exercise energy expenditure and maintained weight loss. The combination of exercise and liraglutide increased cognitive restraint score (13% vs. −9%; P = 0.042), reflecting a conscious restriction of food intake, and decreased sedentary time by 41 min/day (−10 vs. 31 min/day; 95%CI, −82.3 to −0.2; P = 0.049) compared with placebo, which may have facilitated the additional weight loss. Targeting both eating and sedentary behavior could be the most effective for preventing weight regain. Trial registration: EudraCT number, 2015-005585-32; clinicaltrials.gov number, NCT04122716. |
format | Online Article Text |
id | pubmed-9378667 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-93786672022-08-17 Exploratory analysis of eating- and physical activity-related outcomes from a randomized controlled trial for weight loss maintenance with exercise and liraglutide single or combination treatment Jensen, Simon Birk Kjær Janus, Charlotte Lundgren, Julie Rehné Juhl, Christian Rimer Sandsdal, Rasmus Michael Olsen, Lisa Møller Andresen, Anne Borg, Signe Amalie Jacobsen, Ida Christine Finlayson, Graham Stallknecht, Bente Merete Holst, Jens Juul Madsbad, Sten Torekov, Signe Sørensen Nat Commun Article Weight regain after weight loss remains a major challenge in obesity treatment and may involve alteration of eating and sedentary behavior after weight loss. In this randomized, controlled, double-blind trial, adults with obesity were randomized, in a 1:1:1:1 ratio stratified by sex and age group (<40 years and ≥40 years), to one-year weight loss maintenance with exercise, the GLP-1 receptor agonist liraglutide, or the combination, as compared with placebo, after low-calorie diet-induced weight loss. Primary outcome was change in body weight, which has been published. Here, we investigated the effects of weight loss maintenance with exercise, liraglutide, or the combination on weight loss-induced changes in the pre-specified explorative outcomes, eating and sedentary behavior in 130 participants who completed the trial according to the study protocol (exercise (n = 26), liraglutide (n = 36), combination (n = 29), and placebo (n = 39)). One year after weight loss, the placebo group had decreased postprandial appetite suppression score by 14%, and increased sedentary time by 31 min/day and regained weight. Liraglutide prevented the decrease in postprandial appetite suppression score compared with placebo (0% vs. −14%; P = 0.023) and maintained weight loss. Exercise after weight loss did not increase appetite or sedentary behavior compared with placebo, despite increased exercise energy expenditure and maintained weight loss. The combination of exercise and liraglutide increased cognitive restraint score (13% vs. −9%; P = 0.042), reflecting a conscious restriction of food intake, and decreased sedentary time by 41 min/day (−10 vs. 31 min/day; 95%CI, −82.3 to −0.2; P = 0.049) compared with placebo, which may have facilitated the additional weight loss. Targeting both eating and sedentary behavior could be the most effective for preventing weight regain. Trial registration: EudraCT number, 2015-005585-32; clinicaltrials.gov number, NCT04122716. Nature Publishing Group UK 2022-08-15 /pmc/articles/PMC9378667/ /pubmed/35970829 http://dx.doi.org/10.1038/s41467-022-32307-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Jensen, Simon Birk Kjær Janus, Charlotte Lundgren, Julie Rehné Juhl, Christian Rimer Sandsdal, Rasmus Michael Olsen, Lisa Møller Andresen, Anne Borg, Signe Amalie Jacobsen, Ida Christine Finlayson, Graham Stallknecht, Bente Merete Holst, Jens Juul Madsbad, Sten Torekov, Signe Sørensen Exploratory analysis of eating- and physical activity-related outcomes from a randomized controlled trial for weight loss maintenance with exercise and liraglutide single or combination treatment |
title | Exploratory analysis of eating- and physical activity-related outcomes from a randomized controlled trial for weight loss maintenance with exercise and liraglutide single or combination treatment |
title_full | Exploratory analysis of eating- and physical activity-related outcomes from a randomized controlled trial for weight loss maintenance with exercise and liraglutide single or combination treatment |
title_fullStr | Exploratory analysis of eating- and physical activity-related outcomes from a randomized controlled trial for weight loss maintenance with exercise and liraglutide single or combination treatment |
title_full_unstemmed | Exploratory analysis of eating- and physical activity-related outcomes from a randomized controlled trial for weight loss maintenance with exercise and liraglutide single or combination treatment |
title_short | Exploratory analysis of eating- and physical activity-related outcomes from a randomized controlled trial for weight loss maintenance with exercise and liraglutide single or combination treatment |
title_sort | exploratory analysis of eating- and physical activity-related outcomes from a randomized controlled trial for weight loss maintenance with exercise and liraglutide single or combination treatment |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378667/ https://www.ncbi.nlm.nih.gov/pubmed/35970829 http://dx.doi.org/10.1038/s41467-022-32307-y |
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