Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy

Heparanase (HPA) is the predominant enzyme that cleaves heparan sulfate and plays a critical role in a variety of pathophysiological processes. HPA activity has been traditionally correlated with tumor metastasis due to participation in the cleavage and remodeling of the extracellular matrix (ECM)....

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Detalles Bibliográficos
Autores principales: Yang, Min, Tang, Bo, Wang, Sumin, Tang, Li, Wen, Dalin, Vlodavsky, Israel, Yang, Shi-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378687/
https://www.ncbi.nlm.nih.gov/pubmed/35970822
http://dx.doi.org/10.1038/s41389-022-00424-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378687/
https://www.ncbi.nlm.nih.gov/pubmed/35970822
http://dx.doi.org/10.1038/s41389-022-00424-4

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