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Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy
Heparanase (HPA) is the predominant enzyme that cleaves heparan sulfate and plays a critical role in a variety of pathophysiological processes. HPA activity has been traditionally correlated with tumor metastasis due to participation in the cleavage and remodeling of the extracellular matrix (ECM)....
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378687/ https://www.ncbi.nlm.nih.gov/pubmed/35970822 http://dx.doi.org/10.1038/s41389-022-00424-4 |