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Effect of Moxibustion Treatment on Degree Centrality in Patients With Mild Cognitive Impairment: A Resting-State Functional Magnetic Resonance Imaging Study

BACKGROUND: Mild cognitive impairment (MCI) is a common neurological disorder. Moxibustion has been shown to be effective in treating MCI, but its therapeutic mechanisms still remain unclear. This study mainly aimed to investigate the modulation effect of moxibustion treatment for patients with MCI...

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Autores principales: Xu, Ke, Wei, Yichen, Liu, Chengxiang, Zhao, Lihua, Geng, Bowen, Mai, Wei, Zhang, Shuming, Liang, Lingyan, Zeng, Xiao, Deng, Demao, Liu, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378775/
https://www.ncbi.nlm.nih.gov/pubmed/35982690
http://dx.doi.org/10.3389/fnhum.2022.889426
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author Xu, Ke
Wei, Yichen
Liu, Chengxiang
Zhao, Lihua
Geng, Bowen
Mai, Wei
Zhang, Shuming
Liang, Lingyan
Zeng, Xiao
Deng, Demao
Liu, Peng
author_facet Xu, Ke
Wei, Yichen
Liu, Chengxiang
Zhao, Lihua
Geng, Bowen
Mai, Wei
Zhang, Shuming
Liang, Lingyan
Zeng, Xiao
Deng, Demao
Liu, Peng
author_sort Xu, Ke
collection PubMed
description BACKGROUND: Mild cognitive impairment (MCI) is a common neurological disorder. Moxibustion has been shown to be effective in treating MCI, but its therapeutic mechanisms still remain unclear. This study mainly aimed to investigate the modulation effect of moxibustion treatment for patients with MCI by functional magnetic resonance imaging (fMRI). METHODS: A total of 47 patients with MCI and 30 healthy controls (HCs) participated in resting-state fMRI imaging (rs-fMRI) scans. Patients with MCI were randomly divided into true moxibustion group (TRUE, n = 30) and sham moxibustion group (SHAM, n = 17). The degree centrality (DC) approach was applied to distinguish altered brain functions. Correlation analysis was then performed to examine the relationships between the neuroimaging findings and clinical symptoms. RESULTS: Compared with HCs, patients with MCI mainly showed decreased DC in the left middle frontal cortex (MFC) and bilateral middle cingulate cortex (MCC). After moxibustion treatment, the SHAM group had no significant DC findings, while TRUE group mainly showed significant increased DC in the bilateral MFC and MCC, as well as decreased DC in the left middle occipital cortex (MOC). Repeated measures analysis of variance (ANOVA) showed significant interactions between the two groups of patients with MCI. In addition, the higher Mini-Mental State Examination (MMSE) score was significantly positively correlated with increased DC in the right MFC and left MCC after moxibustion treatment. CONCLUSION: Our findings demonstrate that the potential value of moxibustion treatment on MCI, which adds new insights into the popular view that moxibustion treatment may slow cognitive decline in patients with MCI.
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spelling pubmed-93787752022-08-17 Effect of Moxibustion Treatment on Degree Centrality in Patients With Mild Cognitive Impairment: A Resting-State Functional Magnetic Resonance Imaging Study Xu, Ke Wei, Yichen Liu, Chengxiang Zhao, Lihua Geng, Bowen Mai, Wei Zhang, Shuming Liang, Lingyan Zeng, Xiao Deng, Demao Liu, Peng Front Hum Neurosci Neuroscience BACKGROUND: Mild cognitive impairment (MCI) is a common neurological disorder. Moxibustion has been shown to be effective in treating MCI, but its therapeutic mechanisms still remain unclear. This study mainly aimed to investigate the modulation effect of moxibustion treatment for patients with MCI by functional magnetic resonance imaging (fMRI). METHODS: A total of 47 patients with MCI and 30 healthy controls (HCs) participated in resting-state fMRI imaging (rs-fMRI) scans. Patients with MCI were randomly divided into true moxibustion group (TRUE, n = 30) and sham moxibustion group (SHAM, n = 17). The degree centrality (DC) approach was applied to distinguish altered brain functions. Correlation analysis was then performed to examine the relationships between the neuroimaging findings and clinical symptoms. RESULTS: Compared with HCs, patients with MCI mainly showed decreased DC in the left middle frontal cortex (MFC) and bilateral middle cingulate cortex (MCC). After moxibustion treatment, the SHAM group had no significant DC findings, while TRUE group mainly showed significant increased DC in the bilateral MFC and MCC, as well as decreased DC in the left middle occipital cortex (MOC). Repeated measures analysis of variance (ANOVA) showed significant interactions between the two groups of patients with MCI. In addition, the higher Mini-Mental State Examination (MMSE) score was significantly positively correlated with increased DC in the right MFC and left MCC after moxibustion treatment. CONCLUSION: Our findings demonstrate that the potential value of moxibustion treatment on MCI, which adds new insights into the popular view that moxibustion treatment may slow cognitive decline in patients with MCI. Frontiers Media S.A. 2022-08-02 /pmc/articles/PMC9378775/ /pubmed/35982690 http://dx.doi.org/10.3389/fnhum.2022.889426 Text en Copyright © 2022 Xu, Wei, Liu, Zhao, Geng, Mai, Zhang, Liang, Zeng, Deng and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Xu, Ke
Wei, Yichen
Liu, Chengxiang
Zhao, Lihua
Geng, Bowen
Mai, Wei
Zhang, Shuming
Liang, Lingyan
Zeng, Xiao
Deng, Demao
Liu, Peng
Effect of Moxibustion Treatment on Degree Centrality in Patients With Mild Cognitive Impairment: A Resting-State Functional Magnetic Resonance Imaging Study
title Effect of Moxibustion Treatment on Degree Centrality in Patients With Mild Cognitive Impairment: A Resting-State Functional Magnetic Resonance Imaging Study
title_full Effect of Moxibustion Treatment on Degree Centrality in Patients With Mild Cognitive Impairment: A Resting-State Functional Magnetic Resonance Imaging Study
title_fullStr Effect of Moxibustion Treatment on Degree Centrality in Patients With Mild Cognitive Impairment: A Resting-State Functional Magnetic Resonance Imaging Study
title_full_unstemmed Effect of Moxibustion Treatment on Degree Centrality in Patients With Mild Cognitive Impairment: A Resting-State Functional Magnetic Resonance Imaging Study
title_short Effect of Moxibustion Treatment on Degree Centrality in Patients With Mild Cognitive Impairment: A Resting-State Functional Magnetic Resonance Imaging Study
title_sort effect of moxibustion treatment on degree centrality in patients with mild cognitive impairment: a resting-state functional magnetic resonance imaging study
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378775/
https://www.ncbi.nlm.nih.gov/pubmed/35982690
http://dx.doi.org/10.3389/fnhum.2022.889426
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