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The role of osteocalcin in regulation of glycolipid metabolism and muscle function in children with osteogenesis imperfecta

OBJECTIVE: Osteoblasts are discovered to secrete hormones with endocrine effects on metabolism, and osteocalcin (OC) is the most abundant non-collagenous protein in bone. We investigate the relationship between serum OC levels and glycolipid metabolism and muscle function in children with osteogenes...

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Autores principales: Zheng, Wen-bin, Hu, Jing, Zhao, Di-Chen, Zhou, Bing-Na, Wang, Ou, Jiang, Yan, Xia, Wei-Bo, Xing, Xiao-ping, Li, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378831/
https://www.ncbi.nlm.nih.gov/pubmed/35983511
http://dx.doi.org/10.3389/fendo.2022.898645
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author Zheng, Wen-bin
Hu, Jing
Zhao, Di-Chen
Zhou, Bing-Na
Wang, Ou
Jiang, Yan
Xia, Wei-Bo
Xing, Xiao-ping
Li, Mei
author_facet Zheng, Wen-bin
Hu, Jing
Zhao, Di-Chen
Zhou, Bing-Na
Wang, Ou
Jiang, Yan
Xia, Wei-Bo
Xing, Xiao-ping
Li, Mei
author_sort Zheng, Wen-bin
collection PubMed
description OBJECTIVE: Osteoblasts are discovered to secrete hormones with endocrine effects on metabolism, and osteocalcin (OC) is the most abundant non-collagenous protein in bone. We investigate the relationship between serum OC levels and glycolipid metabolism and muscle function in children with osteogenesis imperfecta (OI). METHODS: A total of 225 children with OI and 80 healthy controls matched in age and gender were included in this single center study. Serum levels of fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), low- and high-density lipoprotein cholesterol (LDL-C, HDL-C) were measured by automated analyzers. Serum levels of fasting insulin (FINS) were measured using an automated electrochemiluminescence system. Serum levels of OC and undercarboxylated osteocalcin (ucOC) were measured by enzyme-linked immunosorbent assay. Grip strength and timed-up-and-go (TUG) test were measured. Bone mineral density (BMD) and body composition were measured using dual-energy X-ray absorptiometry. RESULTS: OI patients had significantly higher body mass index (BMI), FBG, and HOMA-IR, but lower HDL-C levels, lower grip strength and longer TUG than control group (all P<0.05). Serum OC, ucOC levels, and ucOC/OC in OI type III patients were significantly lower than those in OI patients with type I and IV. Serum levels of OC, ucOC, and ucOC/OC were negatively correlated to BMI, FBG, insulin levels, and HOMA-IR (all P<0.05). The ratio of ucOC/OC was positively correlated to grip strength (r=0.512, P=0.036), lean mass percentage (%LM) of the total body and limbs, and negatively correlated to fat mass percentage (%FM) of the total body, %FM and fat mass index (FMI) of the trunk (all P<0.05). CONCLUSIONS: Obesity, glucolipid metabolic abnormalities, and reduced grip strength were common in children with OI. Circulating osteocalcin and ucOC may play an important role in the regulation of glucose metabolism, as well as the muscle function of children with OI.
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spelling pubmed-93788312022-08-17 The role of osteocalcin in regulation of glycolipid metabolism and muscle function in children with osteogenesis imperfecta Zheng, Wen-bin Hu, Jing Zhao, Di-Chen Zhou, Bing-Na Wang, Ou Jiang, Yan Xia, Wei-Bo Xing, Xiao-ping Li, Mei Front Endocrinol (Lausanne) Endocrinology OBJECTIVE: Osteoblasts are discovered to secrete hormones with endocrine effects on metabolism, and osteocalcin (OC) is the most abundant non-collagenous protein in bone. We investigate the relationship between serum OC levels and glycolipid metabolism and muscle function in children with osteogenesis imperfecta (OI). METHODS: A total of 225 children with OI and 80 healthy controls matched in age and gender were included in this single center study. Serum levels of fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), low- and high-density lipoprotein cholesterol (LDL-C, HDL-C) were measured by automated analyzers. Serum levels of fasting insulin (FINS) were measured using an automated electrochemiluminescence system. Serum levels of OC and undercarboxylated osteocalcin (ucOC) were measured by enzyme-linked immunosorbent assay. Grip strength and timed-up-and-go (TUG) test were measured. Bone mineral density (BMD) and body composition were measured using dual-energy X-ray absorptiometry. RESULTS: OI patients had significantly higher body mass index (BMI), FBG, and HOMA-IR, but lower HDL-C levels, lower grip strength and longer TUG than control group (all P<0.05). Serum OC, ucOC levels, and ucOC/OC in OI type III patients were significantly lower than those in OI patients with type I and IV. Serum levels of OC, ucOC, and ucOC/OC were negatively correlated to BMI, FBG, insulin levels, and HOMA-IR (all P<0.05). The ratio of ucOC/OC was positively correlated to grip strength (r=0.512, P=0.036), lean mass percentage (%LM) of the total body and limbs, and negatively correlated to fat mass percentage (%FM) of the total body, %FM and fat mass index (FMI) of the trunk (all P<0.05). CONCLUSIONS: Obesity, glucolipid metabolic abnormalities, and reduced grip strength were common in children with OI. Circulating osteocalcin and ucOC may play an important role in the regulation of glucose metabolism, as well as the muscle function of children with OI. Frontiers Media S.A. 2022-08-02 /pmc/articles/PMC9378831/ /pubmed/35983511 http://dx.doi.org/10.3389/fendo.2022.898645 Text en Copyright © 2022 Zheng, Hu, Zhao, Zhou, Wang, Jiang, Xia, Xing and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Zheng, Wen-bin
Hu, Jing
Zhao, Di-Chen
Zhou, Bing-Na
Wang, Ou
Jiang, Yan
Xia, Wei-Bo
Xing, Xiao-ping
Li, Mei
The role of osteocalcin in regulation of glycolipid metabolism and muscle function in children with osteogenesis imperfecta
title The role of osteocalcin in regulation of glycolipid metabolism and muscle function in children with osteogenesis imperfecta
title_full The role of osteocalcin in regulation of glycolipid metabolism and muscle function in children with osteogenesis imperfecta
title_fullStr The role of osteocalcin in regulation of glycolipid metabolism and muscle function in children with osteogenesis imperfecta
title_full_unstemmed The role of osteocalcin in regulation of glycolipid metabolism and muscle function in children with osteogenesis imperfecta
title_short The role of osteocalcin in regulation of glycolipid metabolism and muscle function in children with osteogenesis imperfecta
title_sort role of osteocalcin in regulation of glycolipid metabolism and muscle function in children with osteogenesis imperfecta
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9378831/
https://www.ncbi.nlm.nih.gov/pubmed/35983511
http://dx.doi.org/10.3389/fendo.2022.898645
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