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Reduced glucocorticoid receptor expression in blood mononuclear cells of patients with borderline personality disorder

INTRODUCTION: Abnormal cortisol suppression in borderline personality disorder has been consistently reported in previous studies, suggesting that a hypersensitivity response of the hypothalamic-pituitary-adrenal (HPA) axis might occur in these patients. In this study, the abnormalities of the corti...

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Autores principales: López-Villatoro, José Manuel, MacDowell, Karina S., Diaz-Marsá, Marina, De La Torre-Luque, Alejandro, Prittwitz, Clara, Galvez-Merlin, Alejandra, Leza, Juan C., Carrasco, Jose L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379248/
https://www.ncbi.nlm.nih.gov/pubmed/35982938
http://dx.doi.org/10.3389/fpsyt.2022.951373
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author López-Villatoro, José Manuel
MacDowell, Karina S.
Diaz-Marsá, Marina
De La Torre-Luque, Alejandro
Prittwitz, Clara
Galvez-Merlin, Alejandra
Leza, Juan C.
Carrasco, Jose L.
author_facet López-Villatoro, José Manuel
MacDowell, Karina S.
Diaz-Marsá, Marina
De La Torre-Luque, Alejandro
Prittwitz, Clara
Galvez-Merlin, Alejandra
Leza, Juan C.
Carrasco, Jose L.
author_sort López-Villatoro, José Manuel
collection PubMed
description INTRODUCTION: Abnormal cortisol suppression in borderline personality disorder has been consistently reported in previous studies, suggesting that a hypersensitivity response of the hypothalamic-pituitary-adrenal (HPA) axis might occur in these patients. In this study, the abnormalities of the cortisol response in borderline personality disorder (BPD) are investigated through the cellular expression of the glucocorticoid receptors (GR) in BPD patients and its relationship with traumatic experiences. METHODOLOGY: Sixty-nine male and female patients diagnosed with BPD and 62 healthy controls were studied. Peripheral blood mononuclear cells were obtained to investigate the expression of glucocorticoid receptors. Western blot was used to measure protein expression. Statistical correlations of GR expression with BPD clinical features and intensity of previous traumatic events were investigated. RESULTS: A significant decrease in the nuclear expression of glucocorticoid receptors was found in BPD patients compared to healthy controls in a regression analysis controlling for the effect of medication. GR expression decrease correlated significantly with clinical levels of anxiety and depression, but not with previous traumatic experiences in patients. CONCLUSIONS: BPD patients had a lower nuclear expression of glucocorticoid receptors than healthy controls, when it was controlled for the effect of medication. The reduced GR expression in BPD patients was not associated with previous traumatic events and might be associated with other aspects of BPD, such as emotional instability; more studies with larger samples of patients are still needed to understand the relevance and the implications of these findings.
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spelling pubmed-93792482022-08-17 Reduced glucocorticoid receptor expression in blood mononuclear cells of patients with borderline personality disorder López-Villatoro, José Manuel MacDowell, Karina S. Diaz-Marsá, Marina De La Torre-Luque, Alejandro Prittwitz, Clara Galvez-Merlin, Alejandra Leza, Juan C. Carrasco, Jose L. Front Psychiatry Psychiatry INTRODUCTION: Abnormal cortisol suppression in borderline personality disorder has been consistently reported in previous studies, suggesting that a hypersensitivity response of the hypothalamic-pituitary-adrenal (HPA) axis might occur in these patients. In this study, the abnormalities of the cortisol response in borderline personality disorder (BPD) are investigated through the cellular expression of the glucocorticoid receptors (GR) in BPD patients and its relationship with traumatic experiences. METHODOLOGY: Sixty-nine male and female patients diagnosed with BPD and 62 healthy controls were studied. Peripheral blood mononuclear cells were obtained to investigate the expression of glucocorticoid receptors. Western blot was used to measure protein expression. Statistical correlations of GR expression with BPD clinical features and intensity of previous traumatic events were investigated. RESULTS: A significant decrease in the nuclear expression of glucocorticoid receptors was found in BPD patients compared to healthy controls in a regression analysis controlling for the effect of medication. GR expression decrease correlated significantly with clinical levels of anxiety and depression, but not with previous traumatic experiences in patients. CONCLUSIONS: BPD patients had a lower nuclear expression of glucocorticoid receptors than healthy controls, when it was controlled for the effect of medication. The reduced GR expression in BPD patients was not associated with previous traumatic events and might be associated with other aspects of BPD, such as emotional instability; more studies with larger samples of patients are still needed to understand the relevance and the implications of these findings. Frontiers Media S.A. 2022-08-02 /pmc/articles/PMC9379248/ /pubmed/35982938 http://dx.doi.org/10.3389/fpsyt.2022.951373 Text en Copyright © 2022 López-Villatoro, MacDowell, Diaz-Marsá, De La Torre-Luque, Prittwitz, Galvez-Merlin, Leza and Carrasco. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
López-Villatoro, José Manuel
MacDowell, Karina S.
Diaz-Marsá, Marina
De La Torre-Luque, Alejandro
Prittwitz, Clara
Galvez-Merlin, Alejandra
Leza, Juan C.
Carrasco, Jose L.
Reduced glucocorticoid receptor expression in blood mononuclear cells of patients with borderline personality disorder
title Reduced glucocorticoid receptor expression in blood mononuclear cells of patients with borderline personality disorder
title_full Reduced glucocorticoid receptor expression in blood mononuclear cells of patients with borderline personality disorder
title_fullStr Reduced glucocorticoid receptor expression in blood mononuclear cells of patients with borderline personality disorder
title_full_unstemmed Reduced glucocorticoid receptor expression in blood mononuclear cells of patients with borderline personality disorder
title_short Reduced glucocorticoid receptor expression in blood mononuclear cells of patients with borderline personality disorder
title_sort reduced glucocorticoid receptor expression in blood mononuclear cells of patients with borderline personality disorder
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379248/
https://www.ncbi.nlm.nih.gov/pubmed/35982938
http://dx.doi.org/10.3389/fpsyt.2022.951373
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