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Minimum infective dose of severe acute respiratory syndrome coronavirus 2 based on the current evidence: A systematic review

OBJECTIVE: Understanding the minimum infective dose is significant for risk assessment in the performance of suitable infection control strategies in healthcare centers. However, the literature lacks strong evidence regarding this value for severe acute respiratory syndrome coronavirus 2. Therefore,...

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Autores principales: SeyedAlinaghi, SeyedAhmad, Karimi, Amirali, Mojdeganlou, Hengameh, Pashaei, Zahra, Mirzapour, Pegah, Shamsabadi, Ahmadreza, Barzegary, Alireza, Afroughi, Fatemeh, Dehghani, Soheil, Janfaza, Nazanin, Fakhfouri, Amirata, Khodaei, Sepideh, Mehraeen, Esmaeil, Dadras, Omid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379270/
https://www.ncbi.nlm.nih.gov/pubmed/35983085
http://dx.doi.org/10.1177/20503121221115053
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author SeyedAlinaghi, SeyedAhmad
Karimi, Amirali
Mojdeganlou, Hengameh
Pashaei, Zahra
Mirzapour, Pegah
Shamsabadi, Ahmadreza
Barzegary, Alireza
Afroughi, Fatemeh
Dehghani, Soheil
Janfaza, Nazanin
Fakhfouri, Amirata
Khodaei, Sepideh
Mehraeen, Esmaeil
Dadras, Omid
author_facet SeyedAlinaghi, SeyedAhmad
Karimi, Amirali
Mojdeganlou, Hengameh
Pashaei, Zahra
Mirzapour, Pegah
Shamsabadi, Ahmadreza
Barzegary, Alireza
Afroughi, Fatemeh
Dehghani, Soheil
Janfaza, Nazanin
Fakhfouri, Amirata
Khodaei, Sepideh
Mehraeen, Esmaeil
Dadras, Omid
author_sort SeyedAlinaghi, SeyedAhmad
collection PubMed
description OBJECTIVE: Understanding the minimum infective dose is significant for risk assessment in the performance of suitable infection control strategies in healthcare centers. However, the literature lacks strong evidence regarding this value for severe acute respiratory syndrome coronavirus 2. Therefore, the aim of this study was to investigate the minimum infectious dose of coronavirus disease 2019. METHODS: We searched the databases of PubMed, Scopus, Web of Science, and Cochrane and retrieved all the relevant literature by 25 July 2021. The records were downloaded into the EndNote software and underwent title/abstract and full-text screenings. A summary of included studies was organized into tables for further analysis, interpretation, and drafting of the results. RESULTS: Nineteen studies including the laboratory data on human and animal hosts were selected based on the eligibility criteria. All the literature reported on the infective dose, particularly in humans. The main methods for measurement of infection were through tissue culture infectious dose (TCID50) and counting plaque-forming units. The range of minimum infective was 1.26–7 × 10(6.25) PFU. CONCLUSION: In this study, we have presented a range of minimum infective doses in humans and various animal species. Such numbers can possibly vary between the individuals based on numerous demographic, immunologic, or other factors.
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spelling pubmed-93792702022-08-17 Minimum infective dose of severe acute respiratory syndrome coronavirus 2 based on the current evidence: A systematic review SeyedAlinaghi, SeyedAhmad Karimi, Amirali Mojdeganlou, Hengameh Pashaei, Zahra Mirzapour, Pegah Shamsabadi, Ahmadreza Barzegary, Alireza Afroughi, Fatemeh Dehghani, Soheil Janfaza, Nazanin Fakhfouri, Amirata Khodaei, Sepideh Mehraeen, Esmaeil Dadras, Omid SAGE Open Med Systematic Review OBJECTIVE: Understanding the minimum infective dose is significant for risk assessment in the performance of suitable infection control strategies in healthcare centers. However, the literature lacks strong evidence regarding this value for severe acute respiratory syndrome coronavirus 2. Therefore, the aim of this study was to investigate the minimum infectious dose of coronavirus disease 2019. METHODS: We searched the databases of PubMed, Scopus, Web of Science, and Cochrane and retrieved all the relevant literature by 25 July 2021. The records were downloaded into the EndNote software and underwent title/abstract and full-text screenings. A summary of included studies was organized into tables for further analysis, interpretation, and drafting of the results. RESULTS: Nineteen studies including the laboratory data on human and animal hosts were selected based on the eligibility criteria. All the literature reported on the infective dose, particularly in humans. The main methods for measurement of infection were through tissue culture infectious dose (TCID50) and counting plaque-forming units. The range of minimum infective was 1.26–7 × 10(6.25) PFU. CONCLUSION: In this study, we have presented a range of minimum infective doses in humans and various animal species. Such numbers can possibly vary between the individuals based on numerous demographic, immunologic, or other factors. SAGE Publications 2022-08-11 /pmc/articles/PMC9379270/ /pubmed/35983085 http://dx.doi.org/10.1177/20503121221115053 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Systematic Review
SeyedAlinaghi, SeyedAhmad
Karimi, Amirali
Mojdeganlou, Hengameh
Pashaei, Zahra
Mirzapour, Pegah
Shamsabadi, Ahmadreza
Barzegary, Alireza
Afroughi, Fatemeh
Dehghani, Soheil
Janfaza, Nazanin
Fakhfouri, Amirata
Khodaei, Sepideh
Mehraeen, Esmaeil
Dadras, Omid
Minimum infective dose of severe acute respiratory syndrome coronavirus 2 based on the current evidence: A systematic review
title Minimum infective dose of severe acute respiratory syndrome coronavirus 2 based on the current evidence: A systematic review
title_full Minimum infective dose of severe acute respiratory syndrome coronavirus 2 based on the current evidence: A systematic review
title_fullStr Minimum infective dose of severe acute respiratory syndrome coronavirus 2 based on the current evidence: A systematic review
title_full_unstemmed Minimum infective dose of severe acute respiratory syndrome coronavirus 2 based on the current evidence: A systematic review
title_short Minimum infective dose of severe acute respiratory syndrome coronavirus 2 based on the current evidence: A systematic review
title_sort minimum infective dose of severe acute respiratory syndrome coronavirus 2 based on the current evidence: a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379270/
https://www.ncbi.nlm.nih.gov/pubmed/35983085
http://dx.doi.org/10.1177/20503121221115053
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