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Positive Phospho-Focal Adhesion Kinase in Gastric Cancer Associates With Poor Prognosis After Curative Resection

Gastric cancer (GC) is the fifth most commonly diagnosed cancer and usually has a dismal prognosis. Our previous study highlights the contribution of focal adhesion kinase (FAK) in the tumorigenesis of diffuse gastric cancer (DGC), a subtype of GC according to Lauren classification. The prognostic v...

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Autores principales: Peng, Ke, Li, Suyao, Li, Qian, Zhang, Chenlu, Yuan, Yitao, Liu, Menglin, Zhang, Lei, Wang, Yichen, Yu, Shan, Zhang, Haisheng, Liu, Tianshu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379279/
https://www.ncbi.nlm.nih.gov/pubmed/35982966
http://dx.doi.org/10.3389/fonc.2022.953938
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author Peng, Ke
Li, Suyao
Li, Qian
Zhang, Chenlu
Yuan, Yitao
Liu, Menglin
Zhang, Lei
Wang, Yichen
Yu, Shan
Zhang, Haisheng
Liu, Tianshu
author_facet Peng, Ke
Li, Suyao
Li, Qian
Zhang, Chenlu
Yuan, Yitao
Liu, Menglin
Zhang, Lei
Wang, Yichen
Yu, Shan
Zhang, Haisheng
Liu, Tianshu
author_sort Peng, Ke
collection PubMed
description Gastric cancer (GC) is the fifth most commonly diagnosed cancer and usually has a dismal prognosis. Our previous study highlights the contribution of focal adhesion kinase (FAK) in the tumorigenesis of diffuse gastric cancer (DGC), a subtype of GC according to Lauren classification. The prognostic value of phosphorylated FAK (pFAK) in GC remains to be explored. To explore the prognostic value of pFAK, we retrospectively collected 176 formalin-fixed paraffin-embedded (FFPE) tumor tissues from GC patients who underwent D2 gastrectomy without neoadjuvant treatment. The immunohistochemistry (IHC) staining of pFAK was performed. Survival analysis was performed by Kaplan–Meier and risk factors were evaluated by Cox regression analysis. A pFAK-based nomogram was also constructed for the prediction of overall survival (OS). We demonstrated that the prognosis of pFAK-positive patients was worse than that of the pFAK-negative patients in GC (p = 0.010; hazard ratio [HR] = 1.777, 95% CI 1.131 to 2.791; median OS, 46.6 vs. 86.3 months, respectively), and positive pFAK was also an independent risk factor for the worse prognosis of GC (p = 0.0054; HR = 1.89, 95% CI 1.21–2.96). Moreover, the nomogram based on pFAK and other independent risk factors could improve predictive accuracy for prognosis of GC. In conclusion, through analysis of a large collection of clinically annotated GC samples, we demonstrate that pFAK is a negative prognostic factor in GC, and a nomogram integrating pFAK could help predict OS for GC patients.
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spelling pubmed-93792792022-08-17 Positive Phospho-Focal Adhesion Kinase in Gastric Cancer Associates With Poor Prognosis After Curative Resection Peng, Ke Li, Suyao Li, Qian Zhang, Chenlu Yuan, Yitao Liu, Menglin Zhang, Lei Wang, Yichen Yu, Shan Zhang, Haisheng Liu, Tianshu Front Oncol Oncology Gastric cancer (GC) is the fifth most commonly diagnosed cancer and usually has a dismal prognosis. Our previous study highlights the contribution of focal adhesion kinase (FAK) in the tumorigenesis of diffuse gastric cancer (DGC), a subtype of GC according to Lauren classification. The prognostic value of phosphorylated FAK (pFAK) in GC remains to be explored. To explore the prognostic value of pFAK, we retrospectively collected 176 formalin-fixed paraffin-embedded (FFPE) tumor tissues from GC patients who underwent D2 gastrectomy without neoadjuvant treatment. The immunohistochemistry (IHC) staining of pFAK was performed. Survival analysis was performed by Kaplan–Meier and risk factors were evaluated by Cox regression analysis. A pFAK-based nomogram was also constructed for the prediction of overall survival (OS). We demonstrated that the prognosis of pFAK-positive patients was worse than that of the pFAK-negative patients in GC (p = 0.010; hazard ratio [HR] = 1.777, 95% CI 1.131 to 2.791; median OS, 46.6 vs. 86.3 months, respectively), and positive pFAK was also an independent risk factor for the worse prognosis of GC (p = 0.0054; HR = 1.89, 95% CI 1.21–2.96). Moreover, the nomogram based on pFAK and other independent risk factors could improve predictive accuracy for prognosis of GC. In conclusion, through analysis of a large collection of clinically annotated GC samples, we demonstrate that pFAK is a negative prognostic factor in GC, and a nomogram integrating pFAK could help predict OS for GC patients. Frontiers Media S.A. 2022-08-02 /pmc/articles/PMC9379279/ /pubmed/35982966 http://dx.doi.org/10.3389/fonc.2022.953938 Text en Copyright © 2022 Peng, Li, Li, Zhang, Yuan, Liu, Zhang, Wang, Yu, Zhang and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Peng, Ke
Li, Suyao
Li, Qian
Zhang, Chenlu
Yuan, Yitao
Liu, Menglin
Zhang, Lei
Wang, Yichen
Yu, Shan
Zhang, Haisheng
Liu, Tianshu
Positive Phospho-Focal Adhesion Kinase in Gastric Cancer Associates With Poor Prognosis After Curative Resection
title Positive Phospho-Focal Adhesion Kinase in Gastric Cancer Associates With Poor Prognosis After Curative Resection
title_full Positive Phospho-Focal Adhesion Kinase in Gastric Cancer Associates With Poor Prognosis After Curative Resection
title_fullStr Positive Phospho-Focal Adhesion Kinase in Gastric Cancer Associates With Poor Prognosis After Curative Resection
title_full_unstemmed Positive Phospho-Focal Adhesion Kinase in Gastric Cancer Associates With Poor Prognosis After Curative Resection
title_short Positive Phospho-Focal Adhesion Kinase in Gastric Cancer Associates With Poor Prognosis After Curative Resection
title_sort positive phospho-focal adhesion kinase in gastric cancer associates with poor prognosis after curative resection
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379279/
https://www.ncbi.nlm.nih.gov/pubmed/35982966
http://dx.doi.org/10.3389/fonc.2022.953938
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