T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation

Upon antigen recognition by the T cell receptor (TCR), a complex signaling network orchestrated by protein-tyrosine kinases (PTKs) and protein-tyrosine phosphatases (PTPs) regulates the transmission of the extracellular signal to the nucleus. The role of the PTPs Src-homology 2 (SH2) domain-containi...

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Detalles Bibliográficos
Autores principales: Cammann, Clemens, Israel, Nicole, Frentzel, Sarah, Jeron, Andreas, Topfstedt, Eylin, Schüler, Thomas, Simeoni, Luca, Zenker, Martin, Fehling, Hans Joerg, Schraven, Burkhart, Bruder, Dunja, Seifert, Ulrike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379337/
https://www.ncbi.nlm.nih.gov/pubmed/35983034
http://dx.doi.org/10.3389/fimmu.2022.958616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379337/
https://www.ncbi.nlm.nih.gov/pubmed/35983034
http://dx.doi.org/10.3389/fimmu.2022.958616

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