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Constitutive Activation of the Tumor Suppressor p53 in Hepatocytes Paradoxically Promotes Non–Cell Autonomous Liver Carcinogenesis

In chronic liver diseases (CLD), p53 is constitutively activated in hepatocytes due to various etiologies as viral infection, ethanol exposure, or lipid accumulation. This study was aimed to clarify the significance of p53 activation on the pathophysiology of CLDs. In Kras-mutant liver cancer model,...

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Detalles Bibliográficos
Autores principales:	Makino, Yuki, Hikita, Hayato, Fukumoto, Kenji, Sung, Ji Hyun, Sakano, Yoshihiro, Murai, Kazuhiro, Sakane, Sadatsugu, Kodama, Takahiro, Sakamori, Ryotaro, Kondo, Jumpei, Kobayashi, Shogo, Tatsumi, Tomohide, Takehara, Tetsuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2022
Materias:	Molecular Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379366/ https://www.ncbi.nlm.nih.gov/pubmed/35696550 http://dx.doi.org/10.1158/0008-5472.CAN-21-4390

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