Tubule-mitophagic secretion of SerpinG1 reprograms macrophages to instruct anti-septic acute kidney injury efficacy of high-dose ascorbate mediated by NRF2 transactivation

High-dose ascorbate confers tubular mitophagy responsible for septic acute kidney injury (AKI) amelioration, yet its biological roles in immune regulation remain poorly understood. Methods: The role of tubular mitophagy in macrophage polarization upon high-dose ascorbate treatment was assessed by fl...

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Detalles Bibliográficos
Autores principales: Ni, Yin, Wu, Guo-Hua, Cai, Juan-Juan, Zhang, Run, Zheng, Yang, Liu, Jing-Quan, Yang, Xiang-Hong, Yang, Xue, Shen, Ye, Lai, Jun-Mei, Ye, Xiang-Ming, Mo, Shi-Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379417/
https://www.ncbi.nlm.nih.gov/pubmed/35982894
http://dx.doi.org/10.7150/ijbs.74430

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