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Histone deacetylase-2 controls IL-1β production through the regulation of NLRP3 expression and activation in tuberculosis infection

Histone deacetylases (HDACs) are critical immune regulators. However, their roles in interleukin-1β (IL-1β) production remain unclear. By screening 11 zinc-dependent HDACs with chemical inhibitors, we found that HDAC1 inhibitor, 4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide (DHOB), enh...

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Detalles Bibliográficos
Autores principales:	Moreira, Jôsimar Dornelas, Iakhiaev, Alexei, Vankayalapati, Ramakrishna, Jung, Bock-Gie, Samten, Buka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379586/ https://www.ncbi.nlm.nih.gov/pubmed/35982796 http://dx.doi.org/10.1016/j.isci.2022.104799

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