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LGP2 is essential for zebrafish survival through dual regulation of IFN antiviral response

In mammals, LGP2 is the enigmatic RLR family member, being initially believed as an inhibitor of RLR-triggered IFN response but subsequently as an activator of MDA5 signaling and an inhibitor of RIG-I signaling. The contradiction happens to fish LGP2. Here, we generate a lgp2 loss-of-function (lgp2(...

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Detalles Bibliográficos
Autores principales:	Gong, Xiu-Ying, Zhang, Qi-Min, Zhao, Xiang, Li, Yi-Lin, Qu, Zi-Ling, Li, Zhi, Dan, Cheng, Gui, Jian-Fang, Zhang, Yi-Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379684/ https://www.ncbi.nlm.nih.gov/pubmed/35982787 http://dx.doi.org/10.1016/j.isci.2022.104821

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