Advances in the Biological Functions and Mechanisms of miRNAs in the Development of Osteosarcoma

Osteosarcoma is one of the most common primary malignant bone tumors, mainly occurring in children and adolescents, and is characterized by high morbidity and poor prognosis. MicroRNAs, a class of noncoding RNAs consisting of 19 to 25 nucleotides, are involved in cell proliferation, invasion, metast...

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Autores principales: Dong, Zihe, Liao, Zhipeng, He, Yonglin, Wu, Chengye, Meng, Zixiang, Qin, Baolong, Xu, Ge, Li, Zeyang, Sun, Tianxin, Wen, Yuyan, Li, Guangjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379803/
https://www.ncbi.nlm.nih.gov/pubmed/35950243
http://dx.doi.org/10.1177/15330338221117386
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author Dong, Zihe
Liao, Zhipeng
He, Yonglin
Wu, Chengye
Meng, Zixiang
Qin, Baolong
Xu, Ge
Li, Zeyang
Sun, Tianxin
Wen, Yuyan
Li, Guangjie
author_facet Dong, Zihe
Liao, Zhipeng
He, Yonglin
Wu, Chengye
Meng, Zixiang
Qin, Baolong
Xu, Ge
Li, Zeyang
Sun, Tianxin
Wen, Yuyan
Li, Guangjie
author_sort Dong, Zihe
collection PubMed
description Osteosarcoma is one of the most common primary malignant bone tumors, mainly occurring in children and adolescents, and is characterized by high morbidity and poor prognosis. MicroRNAs, a class of noncoding RNAs consisting of 19 to 25 nucleotides, are involved in cell proliferation, invasion, metastasis, and apoptosis to regulate the development and progression of osteosarcoma. Studies have found that microRNAs are closely related to the diagnosis, treatment, and prognosis of osteosarcoma patients and have an important role in improving drug resistance in osteosarcoma. This paper reviews the role of microRNAs in the pathogenesis of osteosarcoma and their clinical value, aiming to provide a new research direction for diagnosing and treating osteosarcoma and achieving a better prognosis.
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spelling pubmed-93798032022-08-17 Advances in the Biological Functions and Mechanisms of miRNAs in the Development of Osteosarcoma Dong, Zihe Liao, Zhipeng He, Yonglin Wu, Chengye Meng, Zixiang Qin, Baolong Xu, Ge Li, Zeyang Sun, Tianxin Wen, Yuyan Li, Guangjie Technol Cancer Res Treat Review Osteosarcoma is one of the most common primary malignant bone tumors, mainly occurring in children and adolescents, and is characterized by high morbidity and poor prognosis. MicroRNAs, a class of noncoding RNAs consisting of 19 to 25 nucleotides, are involved in cell proliferation, invasion, metastasis, and apoptosis to regulate the development and progression of osteosarcoma. Studies have found that microRNAs are closely related to the diagnosis, treatment, and prognosis of osteosarcoma patients and have an important role in improving drug resistance in osteosarcoma. This paper reviews the role of microRNAs in the pathogenesis of osteosarcoma and their clinical value, aiming to provide a new research direction for diagnosing and treating osteosarcoma and achieving a better prognosis. SAGE Publications 2022-08-10 /pmc/articles/PMC9379803/ /pubmed/35950243 http://dx.doi.org/10.1177/15330338221117386 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Dong, Zihe
Liao, Zhipeng
He, Yonglin
Wu, Chengye
Meng, Zixiang
Qin, Baolong
Xu, Ge
Li, Zeyang
Sun, Tianxin
Wen, Yuyan
Li, Guangjie
Advances in the Biological Functions and Mechanisms of miRNAs in the Development of Osteosarcoma
title Advances in the Biological Functions and Mechanisms of miRNAs in the Development of Osteosarcoma
title_full Advances in the Biological Functions and Mechanisms of miRNAs in the Development of Osteosarcoma
title_fullStr Advances in the Biological Functions and Mechanisms of miRNAs in the Development of Osteosarcoma
title_full_unstemmed Advances in the Biological Functions and Mechanisms of miRNAs in the Development of Osteosarcoma
title_short Advances in the Biological Functions and Mechanisms of miRNAs in the Development of Osteosarcoma
title_sort advances in the biological functions and mechanisms of mirnas in the development of osteosarcoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379803/
https://www.ncbi.nlm.nih.gov/pubmed/35950243
http://dx.doi.org/10.1177/15330338221117386
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