Role of Therapeutic Drug Monitoring in the Treatment of Persistent Mycobacterium abscessus Central Nervous System Infection: A Case Report and Review of the Literature

A patient presenting with recurrent ventriculoperitoneal shunt infection was found to have Mycobacterium abscessus growing from cerebrospinal fluid (CSF), which remained persistently positive. Therapeutic monitoring of clarithromycin, imipenem, and linezolid in CSF and plasma revealed lower than exp...

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Autores principales: Wu, En-Ling, Al-Heeti, Omar, Hoff, Brian M, Williams, Janna L, Krueger, Karen M, Santoiemma, Phillip P, Rhodes, Nathaniel J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379816/
https://www.ncbi.nlm.nih.gov/pubmed/35983263
http://dx.doi.org/10.1093/ofid/ofac392
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author Wu, En-Ling
Al-Heeti, Omar
Hoff, Brian M
Williams, Janna L
Krueger, Karen M
Santoiemma, Phillip P
Rhodes, Nathaniel J
author_facet Wu, En-Ling
Al-Heeti, Omar
Hoff, Brian M
Williams, Janna L
Krueger, Karen M
Santoiemma, Phillip P
Rhodes, Nathaniel J
author_sort Wu, En-Ling
collection PubMed
description A patient presenting with recurrent ventriculoperitoneal shunt infection was found to have Mycobacterium abscessus growing from cerebrospinal fluid (CSF), which remained persistently positive. Therapeutic monitoring of clarithromycin, imipenem, and linezolid in CSF and plasma revealed lower than expected concentrations, prompting alternative therapy and culture clearance on hospital day 42.
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spelling pubmed-93798162022-08-17 Role of Therapeutic Drug Monitoring in the Treatment of Persistent Mycobacterium abscessus Central Nervous System Infection: A Case Report and Review of the Literature Wu, En-Ling Al-Heeti, Omar Hoff, Brian M Williams, Janna L Krueger, Karen M Santoiemma, Phillip P Rhodes, Nathaniel J Open Forum Infect Dis Brief Report A patient presenting with recurrent ventriculoperitoneal shunt infection was found to have Mycobacterium abscessus growing from cerebrospinal fluid (CSF), which remained persistently positive. Therapeutic monitoring of clarithromycin, imipenem, and linezolid in CSF and plasma revealed lower than expected concentrations, prompting alternative therapy and culture clearance on hospital day 42. Oxford University Press 2022-07-30 /pmc/articles/PMC9379816/ /pubmed/35983263 http://dx.doi.org/10.1093/ofid/ofac392 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Wu, En-Ling
Al-Heeti, Omar
Hoff, Brian M
Williams, Janna L
Krueger, Karen M
Santoiemma, Phillip P
Rhodes, Nathaniel J
Role of Therapeutic Drug Monitoring in the Treatment of Persistent Mycobacterium abscessus Central Nervous System Infection: A Case Report and Review of the Literature
title Role of Therapeutic Drug Monitoring in the Treatment of Persistent Mycobacterium abscessus Central Nervous System Infection: A Case Report and Review of the Literature
title_full Role of Therapeutic Drug Monitoring in the Treatment of Persistent Mycobacterium abscessus Central Nervous System Infection: A Case Report and Review of the Literature
title_fullStr Role of Therapeutic Drug Monitoring in the Treatment of Persistent Mycobacterium abscessus Central Nervous System Infection: A Case Report and Review of the Literature
title_full_unstemmed Role of Therapeutic Drug Monitoring in the Treatment of Persistent Mycobacterium abscessus Central Nervous System Infection: A Case Report and Review of the Literature
title_short Role of Therapeutic Drug Monitoring in the Treatment of Persistent Mycobacterium abscessus Central Nervous System Infection: A Case Report and Review of the Literature
title_sort role of therapeutic drug monitoring in the treatment of persistent mycobacterium abscessus central nervous system infection: a case report and review of the literature
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379816/
https://www.ncbi.nlm.nih.gov/pubmed/35983263
http://dx.doi.org/10.1093/ofid/ofac392
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