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QM/MM Simulations Reveal the Determinants of Carbapenemase Activity in Class A β-Lactamases

[Image: see text] β-lactam antibiotic resistance in Gram-negative bacteria, primarily caused by β-lactamase enzymes that hydrolyze the β-lactam ring, has become a serious clinical problem. Carbapenems were formerly considered “last resort” antibiotics because they escaped breakdown by most β-lactama...

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Detalles Bibliográficos
Autores principales:	Chudyk, Ewa I., Beer, Michael, Limb, Michael A. L., Jones, Charlotte A., Spencer, James, van der Kamp, Marc W., Mulholland, Adrian J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379904/ https://www.ncbi.nlm.nih.gov/pubmed/35877936 http://dx.doi.org/10.1021/acsinfecdis.2c00152

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