Spikes and High Frequency Oscillations in Lateral Neocortical Temporal Lobe Epilepsy: Can They Predict the Success Chance of Hippocampus-Sparing Resections?

PURPOSE: We investigated the distribution of spikes and HFOs recorded during intraoperative electrocorticography (ioECoG) and tried to elaborate a predictive model for postsurgical outcomes of patients with lateral neocortical temporal lobe epilepsy (TLE) whose mesiotemporal structures are left in s...

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Autores principales: Maccabeo, Alessandra, van 't Klooster, Maryse A., Schaft, Eline, Demuru, Matteo, Zweiphenning, Willemiek, Gosselaar, Peter, Gebbink, Tineke, Otte, Wim M., Zijlmans, Maeike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379925/
https://www.ncbi.nlm.nih.gov/pubmed/35983430
http://dx.doi.org/10.3389/fneur.2022.797075
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author Maccabeo, Alessandra
van 't Klooster, Maryse A.
Schaft, Eline
Demuru, Matteo
Zweiphenning, Willemiek
Gosselaar, Peter
Gebbink, Tineke
Otte, Wim M.
Zijlmans, Maeike
author_facet Maccabeo, Alessandra
van 't Klooster, Maryse A.
Schaft, Eline
Demuru, Matteo
Zweiphenning, Willemiek
Gosselaar, Peter
Gebbink, Tineke
Otte, Wim M.
Zijlmans, Maeike
author_sort Maccabeo, Alessandra
collection PubMed
description PURPOSE: We investigated the distribution of spikes and HFOs recorded during intraoperative electrocorticography (ioECoG) and tried to elaborate a predictive model for postsurgical outcomes of patients with lateral neocortical temporal lobe epilepsy (TLE) whose mesiotemporal structures are left in situ. METHODS: We selected patients with temporal lateral neocortical epilepsy focus who underwent ioECoG-tailored resections without amygdalo–hippocampectomies. We visually marked spikes, ripples (80–250 Hz), and fast ripples (FRs; 250–500 Hz) on neocortical and mesiotemporal channels before and after resections. We looked for differences in event rates and resection ratios between good (Engel 1A) and poor outcome groups and performed logistic regression analysis to identify outcome predictors. RESULTS: Fourteen out of 24 included patients had a good outcome. The poor-outcome patients showed higher rates of ripples on neocortical channels distant from the resection in pre- and post-ioECoG than people with good outcomes (p(pre) = 0.04, p(post) = 0.05). Post-ioECoG FRs were found only in poor-outcome patients (N = 3). A prediction model based on regression analysis showed low rates of mesiotemporal post-ioECoG ripples (OR(mesio) = 0.13, p(mesio) = 0.04) and older age at epilepsy onset (OR = 1.76, p = 0.04) to be predictors of good seizure outcome. CONCLUSION: HFOs in ioECoG may help to inform the neurosurgeon of the hippocampus-sparing resection success chance in patients with lateral neocortical TLE.
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spelling pubmed-93799252022-08-17 Spikes and High Frequency Oscillations in Lateral Neocortical Temporal Lobe Epilepsy: Can They Predict the Success Chance of Hippocampus-Sparing Resections? Maccabeo, Alessandra van 't Klooster, Maryse A. Schaft, Eline Demuru, Matteo Zweiphenning, Willemiek Gosselaar, Peter Gebbink, Tineke Otte, Wim M. Zijlmans, Maeike Front Neurol Neurology PURPOSE: We investigated the distribution of spikes and HFOs recorded during intraoperative electrocorticography (ioECoG) and tried to elaborate a predictive model for postsurgical outcomes of patients with lateral neocortical temporal lobe epilepsy (TLE) whose mesiotemporal structures are left in situ. METHODS: We selected patients with temporal lateral neocortical epilepsy focus who underwent ioECoG-tailored resections without amygdalo–hippocampectomies. We visually marked spikes, ripples (80–250 Hz), and fast ripples (FRs; 250–500 Hz) on neocortical and mesiotemporal channels before and after resections. We looked for differences in event rates and resection ratios between good (Engel 1A) and poor outcome groups and performed logistic regression analysis to identify outcome predictors. RESULTS: Fourteen out of 24 included patients had a good outcome. The poor-outcome patients showed higher rates of ripples on neocortical channels distant from the resection in pre- and post-ioECoG than people with good outcomes (p(pre) = 0.04, p(post) = 0.05). Post-ioECoG FRs were found only in poor-outcome patients (N = 3). A prediction model based on regression analysis showed low rates of mesiotemporal post-ioECoG ripples (OR(mesio) = 0.13, p(mesio) = 0.04) and older age at epilepsy onset (OR = 1.76, p = 0.04) to be predictors of good seizure outcome. CONCLUSION: HFOs in ioECoG may help to inform the neurosurgeon of the hippocampus-sparing resection success chance in patients with lateral neocortical TLE. Frontiers Media S.A. 2022-08-01 /pmc/articles/PMC9379925/ /pubmed/35983430 http://dx.doi.org/10.3389/fneur.2022.797075 Text en Copyright © 2022 Maccabeo, van 't Klooster, Schaft, Demuru, Zweiphenning, Gosselaar, Gebbink, Otte and Zijlmans. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Maccabeo, Alessandra
van 't Klooster, Maryse A.
Schaft, Eline
Demuru, Matteo
Zweiphenning, Willemiek
Gosselaar, Peter
Gebbink, Tineke
Otte, Wim M.
Zijlmans, Maeike
Spikes and High Frequency Oscillations in Lateral Neocortical Temporal Lobe Epilepsy: Can They Predict the Success Chance of Hippocampus-Sparing Resections?
title Spikes and High Frequency Oscillations in Lateral Neocortical Temporal Lobe Epilepsy: Can They Predict the Success Chance of Hippocampus-Sparing Resections?
title_full Spikes and High Frequency Oscillations in Lateral Neocortical Temporal Lobe Epilepsy: Can They Predict the Success Chance of Hippocampus-Sparing Resections?
title_fullStr Spikes and High Frequency Oscillations in Lateral Neocortical Temporal Lobe Epilepsy: Can They Predict the Success Chance of Hippocampus-Sparing Resections?
title_full_unstemmed Spikes and High Frequency Oscillations in Lateral Neocortical Temporal Lobe Epilepsy: Can They Predict the Success Chance of Hippocampus-Sparing Resections?
title_short Spikes and High Frequency Oscillations in Lateral Neocortical Temporal Lobe Epilepsy: Can They Predict the Success Chance of Hippocampus-Sparing Resections?
title_sort spikes and high frequency oscillations in lateral neocortical temporal lobe epilepsy: can they predict the success chance of hippocampus-sparing resections?
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379925/
https://www.ncbi.nlm.nih.gov/pubmed/35983430
http://dx.doi.org/10.3389/fneur.2022.797075
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