Central nervous system involvement of systemic ALK-positive histiocytosis with KIF5B-ALK fusion

ALK-positive histiocytosis is an emerging histiocytic entity that can involve a single organ or multiple organs. This disease frequently involves the central nervous system, and the importance of immunohistochemical and genetic analyses is emphasized for the accurate diagnosis of this rare entity. H...

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Detalles Bibliográficos
Autores principales: Aoki, Yuzuna, Maeda, Masayuki, Kishi, Seiya, Kogue, Ryota, Tanaka, Fumine, Umino, Maki, Takeoka, Mami, Hanaki, Ryo, Hirayama, Junya, Yuasa, Hiroto, Imai, Hiroshi, Hirayama, Masahiro, Sakuma, Hajime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379947/
https://www.ncbi.nlm.nih.gov/pubmed/35982724
http://dx.doi.org/10.1016/j.radcr.2022.07.072
Descripción
Sumario:ALK-positive histiocytosis is an emerging histiocytic entity that can involve a single organ or multiple organs. This disease frequently involves the central nervous system, and the importance of immunohistochemical and genetic analyses is emphasized for the accurate diagnosis of this rare entity. However, radiological findings of this disease have not been sufficiently described. Here, we report a case of a 3-year-old boy with ALK-positive histiocytosis with systemic masses that was identified to harbor KIF5B-ALK gene fusion.

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