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Central nervous system involvement of systemic ALK-positive histiocytosis with KIF5B-ALK fusion
ALK-positive histiocytosis is an emerging histiocytic entity that can involve a single organ or multiple organs. This disease frequently involves the central nervous system, and the importance of immunohistochemical and genetic analyses is emphasized for the accurate diagnosis of this rare entity. H...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379947/ https://www.ncbi.nlm.nih.gov/pubmed/35982724 http://dx.doi.org/10.1016/j.radcr.2022.07.072 |
| _version_ | 1784768776605007872 |
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| author | Aoki, Yuzuna Maeda, Masayuki Kishi, Seiya Kogue, Ryota Tanaka, Fumine Umino, Maki Takeoka, Mami Hanaki, Ryo Hirayama, Junya Yuasa, Hiroto Imai, Hiroshi Hirayama, Masahiro Sakuma, Hajime |
| author_facet | Aoki, Yuzuna Maeda, Masayuki Kishi, Seiya Kogue, Ryota Tanaka, Fumine Umino, Maki Takeoka, Mami Hanaki, Ryo Hirayama, Junya Yuasa, Hiroto Imai, Hiroshi Hirayama, Masahiro Sakuma, Hajime |
| author_sort | Aoki, Yuzuna |
| collection | PubMed |
| description | ALK-positive histiocytosis is an emerging histiocytic entity that can involve a single organ or multiple organs. This disease frequently involves the central nervous system, and the importance of immunohistochemical and genetic analyses is emphasized for the accurate diagnosis of this rare entity. However, radiological findings of this disease have not been sufficiently described. Here, we report a case of a 3-year-old boy with ALK-positive histiocytosis with systemic masses that was identified to harbor KIF5B-ALK gene fusion. |
| format | Online Article Text |
| id | pubmed-9379947 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-93799472022-08-17 Central nervous system involvement of systemic ALK-positive histiocytosis with KIF5B-ALK fusion Aoki, Yuzuna Maeda, Masayuki Kishi, Seiya Kogue, Ryota Tanaka, Fumine Umino, Maki Takeoka, Mami Hanaki, Ryo Hirayama, Junya Yuasa, Hiroto Imai, Hiroshi Hirayama, Masahiro Sakuma, Hajime Radiol Case Rep Case Report ALK-positive histiocytosis is an emerging histiocytic entity that can involve a single organ or multiple organs. This disease frequently involves the central nervous system, and the importance of immunohistochemical and genetic analyses is emphasized for the accurate diagnosis of this rare entity. However, radiological findings of this disease have not been sufficiently described. Here, we report a case of a 3-year-old boy with ALK-positive histiocytosis with systemic masses that was identified to harbor KIF5B-ALK gene fusion. Elsevier 2022-08-10 /pmc/articles/PMC9379947/ /pubmed/35982724 http://dx.doi.org/10.1016/j.radcr.2022.07.072 Text en © 2022 The Authors. Published by Elsevier Inc. on behalf of University of Washington. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Case Report Aoki, Yuzuna Maeda, Masayuki Kishi, Seiya Kogue, Ryota Tanaka, Fumine Umino, Maki Takeoka, Mami Hanaki, Ryo Hirayama, Junya Yuasa, Hiroto Imai, Hiroshi Hirayama, Masahiro Sakuma, Hajime Central nervous system involvement of systemic ALK-positive histiocytosis with KIF5B-ALK fusion |
| title | Central nervous system involvement of systemic ALK-positive histiocytosis with KIF5B-ALK fusion |
| title_full | Central nervous system involvement of systemic ALK-positive histiocytosis with KIF5B-ALK fusion |
| title_fullStr | Central nervous system involvement of systemic ALK-positive histiocytosis with KIF5B-ALK fusion |
| title_full_unstemmed | Central nervous system involvement of systemic ALK-positive histiocytosis with KIF5B-ALK fusion |
| title_short | Central nervous system involvement of systemic ALK-positive histiocytosis with KIF5B-ALK fusion |
| title_sort | central nervous system involvement of systemic alk-positive histiocytosis with kif5b-alk fusion |
| topic | Case Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379947/ https://www.ncbi.nlm.nih.gov/pubmed/35982724 http://dx.doi.org/10.1016/j.radcr.2022.07.072 |
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