A rare case of sphenoid giant cell tumor: Case report & review of imaging features post short-term denosumab treatment

Background: Giant cell tumors (GCTs) are locally aggressive but rarely malignant bone neoplasms that uncommonly involve the skull. In this report, we describe a tumor of the sphenoid sinus. Case presentation: A 51-year-old female was presented with headache, and bilateral decreased visual acuity, CT...

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Detalles Bibliográficos
Autores principales: Aassouani, Farid, El Bouardi, Nizar, Charifi, Yahya, Maadin, Kaoutar, Bouziane, Amina, Haloua, Meryem, Lamrani, Moulay Youssef Alaoui, Arifi, Samia, Bouhafa, Touria, Boubbou, Meriem, Maaroufi, Mustapha, Alami, Badreeddine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379972/
https://www.ncbi.nlm.nih.gov/pubmed/35982722
http://dx.doi.org/10.1016/j.radcr.2022.07.040
Descripción
Sumario:Background: Giant cell tumors (GCTs) are locally aggressive but rarely malignant bone neoplasms that uncommonly involve the skull. In this report, we describe a tumor of the sphenoid sinus. Case presentation: A 51-year-old female was presented with headache, and bilateral decreased visual acuity, CT scan, and brain MRI revealed an infra-sellar enhancing tumor expanding to the sellar and supra-sellar region which proved to be a GCT. the patient had received 03 months of preoperative denosumab-based treatment and imaging follow-up showed regression in size and morphology modifications of tumor tissue. Conclusion: This is one of few reports to describe the appearance of sphenoid bone GCT, and the first report to highlight the effects of short-term denosumab treatment in GCTb in such a location.

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