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Serum adiponectin-levels are predictive of probable posttraumatic stress disorder in women

BACKGROUND: Accumulative evidence indicates a role for adiponectin, a polypeptide secreted by adipose tissue, in the pathophysiology of posttraumatic disorder (PTSD) via metabolic and inflammatory pathways. This study examined adiponectin as a potential predictive biomarker for PTSD among female rap...

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Autores principales: Vuong, Eileen, Mhlongo, Shibe, Chirwa, Esnat, Lombard, Carl, Peer, Nasheeta, Hemmings, Sian Megan, Abrahams, Naeemah, Seedat, Soraya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379978/
https://www.ncbi.nlm.nih.gov/pubmed/35982731
http://dx.doi.org/10.1016/j.ynstr.2022.100477
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author Vuong, Eileen
Mhlongo, Shibe
Chirwa, Esnat
Lombard, Carl
Peer, Nasheeta
Hemmings, Sian Megan
Abrahams, Naeemah
Seedat, Soraya
author_facet Vuong, Eileen
Mhlongo, Shibe
Chirwa, Esnat
Lombard, Carl
Peer, Nasheeta
Hemmings, Sian Megan
Abrahams, Naeemah
Seedat, Soraya
author_sort Vuong, Eileen
collection PubMed
description BACKGROUND: Accumulative evidence indicates a role for adiponectin, a polypeptide secreted by adipose tissue, in the pathophysiology of posttraumatic disorder (PTSD) via metabolic and inflammatory pathways. This study examined adiponectin as a potential predictive biomarker for PTSD among female rape survivors. METHODS: We evaluated the relationship of baseline serum adiponectin levels to the development of probable PTSD at 3- and 6-months post rape-exposure and compared adiponectin levels between 542 rape-exposed (RE) and 593 rape-unexposed women (RUE). Probable PTSD were defined as Davidson Trauma Scale score ≥40. Data were analysed using multivariate regression models and a generalized estimating equation (GEE) model. We adjusted for clinically relevant covariates associated with PTSD, as well as adiposity indices. RESULTS: Participants who were in the mid-and high adiponectin tertile groups versus the lowest tertile group had a significantly reduced risk of probable PTSD among at 6 months follow-up, independent of adiposity(aOR = 0.45[0.22–1.05], p = 0.035; aOR = 0.44[0.22–0.90], p = 0.024). However, there was no effect of group (RE vs. RUE). LIMITATIONS: Adiponectin assays were conducted on non-fasting blood samples and information on chronic medication, dietary factors and levels of physical activity were not collected. There was a high attrition rate among rape exposed participants. CONCLUSIONS: Our results show that higher serum adiponectin levels are associated with reduced risk of probable PTSD over a 6-month period. This finding supports the hypothesis that serum adiponectin is a potential risk biomarker for PTSD.
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spelling pubmed-93799782022-08-17 Serum adiponectin-levels are predictive of probable posttraumatic stress disorder in women Vuong, Eileen Mhlongo, Shibe Chirwa, Esnat Lombard, Carl Peer, Nasheeta Hemmings, Sian Megan Abrahams, Naeemah Seedat, Soraya Neurobiol Stress Original Research Article BACKGROUND: Accumulative evidence indicates a role for adiponectin, a polypeptide secreted by adipose tissue, in the pathophysiology of posttraumatic disorder (PTSD) via metabolic and inflammatory pathways. This study examined adiponectin as a potential predictive biomarker for PTSD among female rape survivors. METHODS: We evaluated the relationship of baseline serum adiponectin levels to the development of probable PTSD at 3- and 6-months post rape-exposure and compared adiponectin levels between 542 rape-exposed (RE) and 593 rape-unexposed women (RUE). Probable PTSD were defined as Davidson Trauma Scale score ≥40. Data were analysed using multivariate regression models and a generalized estimating equation (GEE) model. We adjusted for clinically relevant covariates associated with PTSD, as well as adiposity indices. RESULTS: Participants who were in the mid-and high adiponectin tertile groups versus the lowest tertile group had a significantly reduced risk of probable PTSD among at 6 months follow-up, independent of adiposity(aOR = 0.45[0.22–1.05], p = 0.035; aOR = 0.44[0.22–0.90], p = 0.024). However, there was no effect of group (RE vs. RUE). LIMITATIONS: Adiponectin assays were conducted on non-fasting blood samples and information on chronic medication, dietary factors and levels of physical activity were not collected. There was a high attrition rate among rape exposed participants. CONCLUSIONS: Our results show that higher serum adiponectin levels are associated with reduced risk of probable PTSD over a 6-month period. This finding supports the hypothesis that serum adiponectin is a potential risk biomarker for PTSD. Elsevier 2022-08-08 /pmc/articles/PMC9379978/ /pubmed/35982731 http://dx.doi.org/10.1016/j.ynstr.2022.100477 Text en © 2022 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Research Article
Vuong, Eileen
Mhlongo, Shibe
Chirwa, Esnat
Lombard, Carl
Peer, Nasheeta
Hemmings, Sian Megan
Abrahams, Naeemah
Seedat, Soraya
Serum adiponectin-levels are predictive of probable posttraumatic stress disorder in women
title Serum adiponectin-levels are predictive of probable posttraumatic stress disorder in women
title_full Serum adiponectin-levels are predictive of probable posttraumatic stress disorder in women
title_fullStr Serum adiponectin-levels are predictive of probable posttraumatic stress disorder in women
title_full_unstemmed Serum adiponectin-levels are predictive of probable posttraumatic stress disorder in women
title_short Serum adiponectin-levels are predictive of probable posttraumatic stress disorder in women
title_sort serum adiponectin-levels are predictive of probable posttraumatic stress disorder in women
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9379978/
https://www.ncbi.nlm.nih.gov/pubmed/35982731
http://dx.doi.org/10.1016/j.ynstr.2022.100477
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