Dissecting the limited genetic overlap of Parkinson's and Alzheimer's disease

Parkinson's disease and Alzheimer's disease show overlapping features both clinically and neuropathologically and elucidating shared mechanisms could have important implications for therapeutic strategies. Evidence for genetic overlap is limited, although enrichment of heritability in geno...

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Detalles Bibliográficos
Autores principales: Stolp Andersen, Maren, Tan, Manuela, Holtman, Inge R., Hardy, John, Pihlstrøm, Lasse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380131/
https://www.ncbi.nlm.nih.gov/pubmed/35684951
http://dx.doi.org/10.1002/acn3.51606
Descripción
Sumario:Parkinson's disease and Alzheimer's disease show overlapping features both clinically and neuropathologically and elucidating shared mechanisms could have important implications for therapeutic strategies. Evidence for genetic overlap is limited, although enrichment of heritability in genomic regions relevant to microglia has been demonstrated in both disorders. Using summary statistics from genome‐wide association studies, we assessed genetic covariance stratified by cell types and local genetic correlation between Parkinson's and Alzheimer's disease. Significant covariance was observed for neurons only (p = 0.00046), and local genetic correlation was significant only in the human leukocyte antigen region (p = 1.0e‐05). Our findings support a minor genetic overlap between these two disorders.

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