Skeletal progenitors preserve proliferation and self-renewal upon inhibition of mitochondrial respiration by rerouting the TCA cycle

A functional electron transport chain (ETC) is crucial for supporting bioenergetics and biosynthesis. Accordingly, ETC inhibition decreases proliferation in cancer cells but does not seem to impair stem cell proliferation. However, it remains unclear how stem cells metabolically adapt. In this study...

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Detalles Bibliográficos
Autores principales: Tournaire, Guillaume, Loopmans, Shauni, Stegen, Steve, Rinaldi, Gianmarco, Eelen, Guy, Torrekens, Sophie, Moermans, Karen, Carmeliet, Peter, Ghesquière, Bart, Thienpont, Bernard, Fendt, Sarah-Maria, van Gastel, Nick, Carmeliet, Geert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380255/
https://www.ncbi.nlm.nih.gov/pubmed/35905715
http://dx.doi.org/10.1016/j.celrep.2022.111105

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