Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes

MHC-E regulates NK cells by displaying MHC class Ia signal peptides (VL9) to NKG2A:CD94 receptors. MHC-E can also present sequence-diverse, lower-affinity, pathogen-derived peptides to T cell receptors (TCRs) on CD8(+) T cells. To understand these affinity differences, human MHC-E (HLA-E)-VL9 versus...

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Detalles Bibliográficos
Autores principales: Walters, Lucy C., Rozbesky, Daniel, Harlos, Karl, Quastel, Max, Sun, Hong, Springer, Sebastian, Rambo, Robert P., Mohammed, Fiyaz, Jones, E. Yvonne, McMichael, Andrew J., Gillespie, Geraldine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380258/
https://www.ncbi.nlm.nih.gov/pubmed/35705051
http://dx.doi.org/10.1016/j.celrep.2022.110959

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