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Patient and Tumour Characteristics of Keratoacanthoma in a Large, Community-based Cohort Study from Queensland, Australia

Keratoacanthomas are common keratinocyte skin tumours. However, there is little community-based data published on the clinical features of keratoacanthoma. The aim of this study was to describe the patient and tumour characteristics of keratoacanthomas, as well as their treatment patterns. Data were...

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Autores principales: KOLMODIN, Agnes, PANDEYA, Nirmala P., OLSEN, Catherine M., DUSINGIZE, Jean Claude, WHITEMAN, David C., CLAESON, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Publication of Acta Dermato-Venereologica 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380270/
https://www.ncbi.nlm.nih.gov/pubmed/33954799
http://dx.doi.org/10.2340/00015555-3824
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author KOLMODIN, Agnes
PANDEYA, Nirmala P.
OLSEN, Catherine M.
DUSINGIZE, Jean Claude
WHITEMAN, David C.
CLAESON, Magdalena
author_facet KOLMODIN, Agnes
PANDEYA, Nirmala P.
OLSEN, Catherine M.
DUSINGIZE, Jean Claude
WHITEMAN, David C.
CLAESON, Magdalena
author_sort KOLMODIN, Agnes
collection PubMed
description Keratoacanthomas are common keratinocyte skin tumours. However, there is little community-based data published on the clinical features of keratoacanthoma. The aim of this study was to describe the patient and tumour characteristics of keratoacanthomas, as well as their treatment patterns. Data were obtained from the QSkin Sun and Health study, a prospective cohort of 40,438 randomly sampled and consented participants aged 40–69 years in Queensland, Australia. In 2010, a baseline survey collected data, including demography, phenotype, ultraviolet radiation exposure, medical history and lifestyle. Histopathological reports of keratoacanthomas arising until 30 June 2014 were reviewed. In total, 584 participants developed 738 keratoacanthomas; 18% of participants developed multiple tumours. Common patient characteristics were male sex (58%), age ≥ 60 years (76%), fair skin (80%), and previous history of actinic keratoses/keratinocyte cancers (89%). Keratoacanthomas were commonly located on the legs/feet (48%), and rarely on the the head/neck (7%). Excision was the most frequently used surgical method (71%) Evidence of histopathological regression was reported in 67% of keratoacanthomas, suggesting a potential for spontaneous resolution in a significant proportion of keratoacanthomas.
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spelling pubmed-93802702022-10-20 Patient and Tumour Characteristics of Keratoacanthoma in a Large, Community-based Cohort Study from Queensland, Australia KOLMODIN, Agnes PANDEYA, Nirmala P. OLSEN, Catherine M. DUSINGIZE, Jean Claude WHITEMAN, David C. CLAESON, Magdalena Acta Derm Venereol Clinical Report Keratoacanthomas are common keratinocyte skin tumours. However, there is little community-based data published on the clinical features of keratoacanthoma. The aim of this study was to describe the patient and tumour characteristics of keratoacanthomas, as well as their treatment patterns. Data were obtained from the QSkin Sun and Health study, a prospective cohort of 40,438 randomly sampled and consented participants aged 40–69 years in Queensland, Australia. In 2010, a baseline survey collected data, including demography, phenotype, ultraviolet radiation exposure, medical history and lifestyle. Histopathological reports of keratoacanthomas arising until 30 June 2014 were reviewed. In total, 584 participants developed 738 keratoacanthomas; 18% of participants developed multiple tumours. Common patient characteristics were male sex (58%), age ≥ 60 years (76%), fair skin (80%), and previous history of actinic keratoses/keratinocyte cancers (89%). Keratoacanthomas were commonly located on the legs/feet (48%), and rarely on the the head/neck (7%). Excision was the most frequently used surgical method (71%) Evidence of histopathological regression was reported in 67% of keratoacanthomas, suggesting a potential for spontaneous resolution in a significant proportion of keratoacanthomas. Society for Publication of Acta Dermato-Venereologica 2021-06-02 /pmc/articles/PMC9380270/ /pubmed/33954799 http://dx.doi.org/10.2340/00015555-3824 Text en © 2021 Acta Dermato-Venereologica https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the CC BY-NC license
spellingShingle Clinical Report
KOLMODIN, Agnes
PANDEYA, Nirmala P.
OLSEN, Catherine M.
DUSINGIZE, Jean Claude
WHITEMAN, David C.
CLAESON, Magdalena
Patient and Tumour Characteristics of Keratoacanthoma in a Large, Community-based Cohort Study from Queensland, Australia
title Patient and Tumour Characteristics of Keratoacanthoma in a Large, Community-based Cohort Study from Queensland, Australia
title_full Patient and Tumour Characteristics of Keratoacanthoma in a Large, Community-based Cohort Study from Queensland, Australia
title_fullStr Patient and Tumour Characteristics of Keratoacanthoma in a Large, Community-based Cohort Study from Queensland, Australia
title_full_unstemmed Patient and Tumour Characteristics of Keratoacanthoma in a Large, Community-based Cohort Study from Queensland, Australia
title_short Patient and Tumour Characteristics of Keratoacanthoma in a Large, Community-based Cohort Study from Queensland, Australia
title_sort patient and tumour characteristics of keratoacanthoma in a large, community-based cohort study from queensland, australia
topic Clinical Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380270/
https://www.ncbi.nlm.nih.gov/pubmed/33954799
http://dx.doi.org/10.2340/00015555-3824
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