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Altered Monocytic Phenotypes are Associated with Uraemic Pruritus in Patients Receiving Haemodialysis

Uraemic pruritus is one of the most bothersome symptoms in patients receiving haemodialysis. A total of 175 patients receiving maintenance haemodialysis, with 74 patients experiencing uraemic pruritus, were prospectively recruited to assess the influence of the phenotype of blood monocytes and vario...

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Autores principales: KO, Mei-Ju, TSAI, Wan-Chuan, PENG, Yu-Sen, HSU, Shih-Ping, PAI, Mei-Fen, YANG, Ju-Yeh, WU, Hon-Yen, CHIU, Yen-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Publication of Acta Dermato-Venereologica 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380278/
https://www.ncbi.nlm.nih.gov/pubmed/34043016
http://dx.doi.org/10.2340/00015555-3841
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author KO, Mei-Ju
TSAI, Wan-Chuan
PENG, Yu-Sen
HSU, Shih-Ping
PAI, Mei-Fen
YANG, Ju-Yeh
WU, Hon-Yen
CHIU, Yen-Ling
author_facet KO, Mei-Ju
TSAI, Wan-Chuan
PENG, Yu-Sen
HSU, Shih-Ping
PAI, Mei-Fen
YANG, Ju-Yeh
WU, Hon-Yen
CHIU, Yen-Ling
author_sort KO, Mei-Ju
collection PubMed
description Uraemic pruritus is one of the most bothersome symptoms in patients receiving haemodialysis. A total of 175 patients receiving maintenance haemodialysis, with 74 patients experiencing uraemic pruritus, were prospectively recruited to assess the influence of the phenotype of blood monocytes and various cytokines on uraemic pruritus. The phenotype of blood monocytes was determined by flow cytometry as classical (CD14(++)CD16(−)) monocytes, non-classical (CD14(+)CD16(++)) monocytes, and intermediate (CD14(++)CD16(+)) monocytes. Eight cytokines, including interleukin (IL)-2, interferon-γ, IL-12p70, IL-4, IL-5, IL-6, tumour necrosis factor-α, and IL-10, were simultaneously detected with a multiplex bead-based immunoassay. Multivariate linear regression analysis showed that a higher percentage of intermediate monocytes (effect estimate 0.08; 95% confidence interval 0.01–0.16) were independent predictors of a higher visual analogue scale score for pruritus intensity. No differences were noted for all 8 cytokines between patients with and without uraemic pruritus. The results of this study indicate that altered monocytic phenotypes could play a role in uraemic pruritus.
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spelling pubmed-93802782022-10-20 Altered Monocytic Phenotypes are Associated with Uraemic Pruritus in Patients Receiving Haemodialysis KO, Mei-Ju TSAI, Wan-Chuan PENG, Yu-Sen HSU, Shih-Ping PAI, Mei-Fen YANG, Ju-Yeh WU, Hon-Yen CHIU, Yen-Ling Acta Derm Venereol Investigative Report Uraemic pruritus is one of the most bothersome symptoms in patients receiving haemodialysis. A total of 175 patients receiving maintenance haemodialysis, with 74 patients experiencing uraemic pruritus, were prospectively recruited to assess the influence of the phenotype of blood monocytes and various cytokines on uraemic pruritus. The phenotype of blood monocytes was determined by flow cytometry as classical (CD14(++)CD16(−)) monocytes, non-classical (CD14(+)CD16(++)) monocytes, and intermediate (CD14(++)CD16(+)) monocytes. Eight cytokines, including interleukin (IL)-2, interferon-γ, IL-12p70, IL-4, IL-5, IL-6, tumour necrosis factor-α, and IL-10, were simultaneously detected with a multiplex bead-based immunoassay. Multivariate linear regression analysis showed that a higher percentage of intermediate monocytes (effect estimate 0.08; 95% confidence interval 0.01–0.16) were independent predictors of a higher visual analogue scale score for pruritus intensity. No differences were noted for all 8 cytokines between patients with and without uraemic pruritus. The results of this study indicate that altered monocytic phenotypes could play a role in uraemic pruritus. Society for Publication of Acta Dermato-Venereologica 2021-06-22 /pmc/articles/PMC9380278/ /pubmed/34043016 http://dx.doi.org/10.2340/00015555-3841 Text en © 2021 Acta Dermato-Venereologica https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the CC BY-NC license
spellingShingle Investigative Report
KO, Mei-Ju
TSAI, Wan-Chuan
PENG, Yu-Sen
HSU, Shih-Ping
PAI, Mei-Fen
YANG, Ju-Yeh
WU, Hon-Yen
CHIU, Yen-Ling
Altered Monocytic Phenotypes are Associated with Uraemic Pruritus in Patients Receiving Haemodialysis
title Altered Monocytic Phenotypes are Associated with Uraemic Pruritus in Patients Receiving Haemodialysis
title_full Altered Monocytic Phenotypes are Associated with Uraemic Pruritus in Patients Receiving Haemodialysis
title_fullStr Altered Monocytic Phenotypes are Associated with Uraemic Pruritus in Patients Receiving Haemodialysis
title_full_unstemmed Altered Monocytic Phenotypes are Associated with Uraemic Pruritus in Patients Receiving Haemodialysis
title_short Altered Monocytic Phenotypes are Associated with Uraemic Pruritus in Patients Receiving Haemodialysis
title_sort altered monocytic phenotypes are associated with uraemic pruritus in patients receiving haemodialysis
topic Investigative Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380278/
https://www.ncbi.nlm.nih.gov/pubmed/34043016
http://dx.doi.org/10.2340/00015555-3841
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