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Nutritional status in female patients with nontuberculous mycobacterial lung disease and its association with disease severity

BACKGROUND: In women, slender body habitus has been reported to be one of the predisposing factors underlying the development and poor prognosis of non-tuberculous mycobacterial lung disease (NTM-LD). Given the lack of nutritional data contributing to treatment strategies, we aimed to clarify the nu...

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Autores principales: Takayama, Yumi, Kitajima, Takamasa, Honda, Noritsugu, Sakane, Naoki, Yumen, Yukina, Fukui, Motonari, Nagai, Narumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380388/
https://www.ncbi.nlm.nih.gov/pubmed/35971083
http://dx.doi.org/10.1186/s12890-022-02109-5
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author Takayama, Yumi
Kitajima, Takamasa
Honda, Noritsugu
Sakane, Naoki
Yumen, Yukina
Fukui, Motonari
Nagai, Narumi
author_facet Takayama, Yumi
Kitajima, Takamasa
Honda, Noritsugu
Sakane, Naoki
Yumen, Yukina
Fukui, Motonari
Nagai, Narumi
author_sort Takayama, Yumi
collection PubMed
description BACKGROUND: In women, slender body habitus has been reported to be one of the predisposing factors underlying the development and poor prognosis of non-tuberculous mycobacterial lung disease (NTM-LD). Given the lack of nutritional data contributing to treatment strategies, we aimed to clarify the nutritional status of female patients with NTM-LD and its association with disease severity. METHODS: In this single-center observational study, we enrolled 81 female outpatients with NTM-LD. Data on healthy women of similar ages were selected from our previous survey data and categorized as controls. First, we compared anthropometric and dietary survey data between patients and controls. Second, after the patients were categorized into relatively mild (mild, n = 40) and relatively severe groups (severe, n = 41) based on pulmonary X-ray-image finding scores, body composition, nutritional intake, and biochemical markers were compared between the groups. To identify nutritional factors associated with disease severity, logistic regression analyses were performed. RESULTS: Compared with controls, patients with NTM-LD had significantly lower energy intake, body mass index, body fat, and skeletal muscle mass (all p < 0.001). Compared with the mild group, the severe group had significantly lower skeletal muscle mass (p = 0.037), albumin (p = 0.029), transthyretin (prealbumin) (p = 0.002), retinol-binding protein (p = 0.011), and hemoglobin (p = 0.001); however, no between-group differences were observed in energy or nutrient intake. Logistic analyses revealed that transthyretin (p = 0.025) and hemoglobin (p = 0.003) levels were independent factors associated with disease severity. CONCLUSIONS: This is the first study to comprehensively report the association between NTM-LD severity and nutritional status, including body composition, nutrient intake, and biomarkers. The results suggest that initiating nutritional therapy from the mild stage of the disease to prevent undernutrition is warranted. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12890-022-02109-5.
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spelling pubmed-93803882022-08-17 Nutritional status in female patients with nontuberculous mycobacterial lung disease and its association with disease severity Takayama, Yumi Kitajima, Takamasa Honda, Noritsugu Sakane, Naoki Yumen, Yukina Fukui, Motonari Nagai, Narumi BMC Pulm Med Research BACKGROUND: In women, slender body habitus has been reported to be one of the predisposing factors underlying the development and poor prognosis of non-tuberculous mycobacterial lung disease (NTM-LD). Given the lack of nutritional data contributing to treatment strategies, we aimed to clarify the nutritional status of female patients with NTM-LD and its association with disease severity. METHODS: In this single-center observational study, we enrolled 81 female outpatients with NTM-LD. Data on healthy women of similar ages were selected from our previous survey data and categorized as controls. First, we compared anthropometric and dietary survey data between patients and controls. Second, after the patients were categorized into relatively mild (mild, n = 40) and relatively severe groups (severe, n = 41) based on pulmonary X-ray-image finding scores, body composition, nutritional intake, and biochemical markers were compared between the groups. To identify nutritional factors associated with disease severity, logistic regression analyses were performed. RESULTS: Compared with controls, patients with NTM-LD had significantly lower energy intake, body mass index, body fat, and skeletal muscle mass (all p < 0.001). Compared with the mild group, the severe group had significantly lower skeletal muscle mass (p = 0.037), albumin (p = 0.029), transthyretin (prealbumin) (p = 0.002), retinol-binding protein (p = 0.011), and hemoglobin (p = 0.001); however, no between-group differences were observed in energy or nutrient intake. Logistic analyses revealed that transthyretin (p = 0.025) and hemoglobin (p = 0.003) levels were independent factors associated with disease severity. CONCLUSIONS: This is the first study to comprehensively report the association between NTM-LD severity and nutritional status, including body composition, nutrient intake, and biomarkers. The results suggest that initiating nutritional therapy from the mild stage of the disease to prevent undernutrition is warranted. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12890-022-02109-5. BioMed Central 2022-08-15 /pmc/articles/PMC9380388/ /pubmed/35971083 http://dx.doi.org/10.1186/s12890-022-02109-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Takayama, Yumi
Kitajima, Takamasa
Honda, Noritsugu
Sakane, Naoki
Yumen, Yukina
Fukui, Motonari
Nagai, Narumi
Nutritional status in female patients with nontuberculous mycobacterial lung disease and its association with disease severity
title Nutritional status in female patients with nontuberculous mycobacterial lung disease and its association with disease severity
title_full Nutritional status in female patients with nontuberculous mycobacterial lung disease and its association with disease severity
title_fullStr Nutritional status in female patients with nontuberculous mycobacterial lung disease and its association with disease severity
title_full_unstemmed Nutritional status in female patients with nontuberculous mycobacterial lung disease and its association with disease severity
title_short Nutritional status in female patients with nontuberculous mycobacterial lung disease and its association with disease severity
title_sort nutritional status in female patients with nontuberculous mycobacterial lung disease and its association with disease severity
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380388/
https://www.ncbi.nlm.nih.gov/pubmed/35971083
http://dx.doi.org/10.1186/s12890-022-02109-5
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