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Advance directives and real-world end-of-life clinical practice: a case–control study
BACKGROUND: Advance directives (ADs) have been legally regulated to promote autonomy over health decisions among patients who later lose decision-making capacity. AIMS AND OBJECTIVES: To analyse the differences in clinical practice at end of life among people who had completed an AD versus those who...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BMJ Publishing Group
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380474/ https://www.ncbi.nlm.nih.gov/pubmed/33753359 http://dx.doi.org/10.1136/bmjspcare-2020-002851 |
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author | Dalmau-Bueno, Albert Saura-Lazaro, Anna Busquets, Josep Ma Bullich-Marín, Ingrid García-Altés, Anna |
author_facet | Dalmau-Bueno, Albert Saura-Lazaro, Anna Busquets, Josep Ma Bullich-Marín, Ingrid García-Altés, Anna |
author_sort | Dalmau-Bueno, Albert |
collection | PubMed |
description | BACKGROUND: Advance directives (ADs) have been legally regulated to promote autonomy over health decisions among patients who later lose decision-making capacity. AIMS AND OBJECTIVES: To analyse the differences in clinical practice at end of life among people who had completed an AD versus those who had not. METHODS: Retrospective case–control study (1:2), matched by age, sex, year, cause of death and region of residence. The data sources used were the ADs registry, central registry of insured persons, hospital discharge, pharmacy and billing databases, and the mortality registry. Conditional logistic regression models (crude and adjusted by socioeconomic level) were performed. The outcome variable was the frequency of medical procedures performed during the last year of life. RESULTS: 1723 people with ADs who died in Catalonia during 2014–2015 were matched with 3446 dead controls (without ADs). Thoracentesis was the procedure with the greatest reduction among women with an AD (adjusted OR (OR(adj)) 0.54, 95% CI: 0.32 to 0.89) in conjunction with artificial nutrition (OR(adj) 0.54, 95% CI: 0.31 to 0.95). Intubation was the procedure with the greatest reduction (OR(adj) 0.56, 95% CI: 0.33 to 0.94) among men. Slight differences could be seen in the case of cancer deaths. There were no relevant differences when adjusting by socioeconomic level. CONCLUSIONS: ADs are an effective tool to adjust the realisation of some procedures at end of life. These results can help better plan for the treatment of patients with ADs, as well as increase the awareness among clinical personnel, families and the general population. |
format | Online Article Text |
id | pubmed-9380474 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-93804742022-08-30 Advance directives and real-world end-of-life clinical practice: a case–control study Dalmau-Bueno, Albert Saura-Lazaro, Anna Busquets, Josep Ma Bullich-Marín, Ingrid García-Altés, Anna BMJ Support Palliat Care Original Research BACKGROUND: Advance directives (ADs) have been legally regulated to promote autonomy over health decisions among patients who later lose decision-making capacity. AIMS AND OBJECTIVES: To analyse the differences in clinical practice at end of life among people who had completed an AD versus those who had not. METHODS: Retrospective case–control study (1:2), matched by age, sex, year, cause of death and region of residence. The data sources used were the ADs registry, central registry of insured persons, hospital discharge, pharmacy and billing databases, and the mortality registry. Conditional logistic regression models (crude and adjusted by socioeconomic level) were performed. The outcome variable was the frequency of medical procedures performed during the last year of life. RESULTS: 1723 people with ADs who died in Catalonia during 2014–2015 were matched with 3446 dead controls (without ADs). Thoracentesis was the procedure with the greatest reduction among women with an AD (adjusted OR (OR(adj)) 0.54, 95% CI: 0.32 to 0.89) in conjunction with artificial nutrition (OR(adj) 0.54, 95% CI: 0.31 to 0.95). Intubation was the procedure with the greatest reduction (OR(adj) 0.56, 95% CI: 0.33 to 0.94) among men. Slight differences could be seen in the case of cancer deaths. There were no relevant differences when adjusting by socioeconomic level. CONCLUSIONS: ADs are an effective tool to adjust the realisation of some procedures at end of life. These results can help better plan for the treatment of patients with ADs, as well as increase the awareness among clinical personnel, families and the general population. BMJ Publishing Group 2022-08 2021-03-22 /pmc/articles/PMC9380474/ /pubmed/33753359 http://dx.doi.org/10.1136/bmjspcare-2020-002851 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Original Research Dalmau-Bueno, Albert Saura-Lazaro, Anna Busquets, Josep Ma Bullich-Marín, Ingrid García-Altés, Anna Advance directives and real-world end-of-life clinical practice: a case–control study |
title | Advance directives and real-world end-of-life clinical practice: a case–control study |
title_full | Advance directives and real-world end-of-life clinical practice: a case–control study |
title_fullStr | Advance directives and real-world end-of-life clinical practice: a case–control study |
title_full_unstemmed | Advance directives and real-world end-of-life clinical practice: a case–control study |
title_short | Advance directives and real-world end-of-life clinical practice: a case–control study |
title_sort | advance directives and real-world end-of-life clinical practice: a case–control study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380474/ https://www.ncbi.nlm.nih.gov/pubmed/33753359 http://dx.doi.org/10.1136/bmjspcare-2020-002851 |
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